摘要
目的 探讨多囊卵巢综合征(PCOS)患者腹型肥胖、高雄(临床高雄和生化高雄)与胰岛素抵抗(IR)及脂代谢的相关性。方法 回顾性分析2018年1月-10月我院收治的143例PCOS患者临床资料,根据不同肥胖标准分为腹型肥胖组与非腹型肥胖组、整体肥胖组与非整体肥胖组,另根据不同高雄标准分为临床高雄组与非临床高雄组、生化高雄组与非生化高雄组,分析不同标准下的肥胖率及高雄率,肥胖与高雄、IR及脂代谢的关系,高雄与肥胖、IR及血脂指标的关系。结果 纳入的143例PCOS患者中,整体肥胖率为31.47%,腹型肥胖率为48.25%,总IR率为58.74%,总高雄率为85.31%,其中临床高雄率为80.42%,生化高雄率为40.56%。腹型肥胖组与非腹型肥胖组T、TC、TG、HDL-C、HOMA-IR比较,差异有统计学意义(P<0.05),而两组mF-G评分、LDL-C比较,差异无统计学意义(P>0.05);整体肥胖组与非整体肥胖组TC、TG、HDLC、HOMA-IR比较,差异有统计学意义(P <0.05),而两组T、mF-G评分、LDL-C比较,差异无统计学意义(P>0.05);Pearson相关分析显示,WC和BMI与HOMA-IR、TC、TG呈正相关,与HDL-C呈负相关(P<0.05);二者均与LDL-C无相关性(P>0.05);临床高雄组与非临床高雄组及生化高雄组与非生化高雄组肥胖指标、HOMA-IR及脂代谢指标比较,差异无统计学意义(P>0.05);多因素Logistic分析显示,不论是否存在肥胖或是IR均与生化高雄和临床高雄无相关性,血脂相关指标亦与高雄无明显相关性(P>0.05)。结论 PCOS患者主要表现为腹型肥胖,且腹型肥胖患者更易发生糖脂代谢紊乱。临床高雄与生化高雄在诊断PCOS具有同等效力,且不论是否存在高雄,均应重视IR及脂代谢异常,以提高对PCOS患者的诊疗预后。
Objective To investigate the relationship between abdominal obesity,hyperandrogenism,insulin resistance(IR) and lipid metabolism in patients with polycystic ovary syndrome(PCOS).Methods A total of 143 patients with PCOS treated in our hospital from January to October 2018were analyzed.Patients were divided into abdominal obesity group and non-abdominal obesity group,overall obesity group and non-overall obesity group according to different obesity standards.In addition,they were divided into clinical hyperandrogenism group and non-clinical hyperandrogenism group,biochemical hyperandrogenism group and non-biochemical hyperandrogenism group by different hyperandrogenism standards.The obesity rate and hyperandrogenism rate were analyzed under different standards.The relationship between obesity and hyperandrogenism,IR and lipid metabolism,as well as hyperandrogenism and obesity,IR and lipid index were analyzed.Results Among 143patients with PCOS,the overall obesity rate was 31.47%,and abdominal obesity rate was 48.25%,the total IR rate was 58.74%,the total hyperandrogenism rate was 85.31%,while clinical hyperandrogenism rate was 80.42% and the biochemical hyperandrogenism rate was 40.56%.There were statistically significant differences in T,TC,TG,HDL-C and HOMA-IR between abdominal obesity group and non-abdominal obesity group(P<0.05),while there were no statistically significant differences in mF-G score and LDL-C between the two groups( P>0.05).There were statistically significant differences in TC,TG,HDL-C and HOMA-IR between the overall obesity group and the non-overall obesity group( P <0.05),while there were no statistically significant differences in T,mF-G score and LDL-C between the two groups( P>0.05).Pearson correlation analysis showed that WC and BMI were positively correlated with HOMA-IR,TC and TG,but negatively correlated with HDL-C( P<0.05),there was no correlation between LDL-C and LDL-C(P >0.05).There were no significant differences in obesity,HOMA-IR and lipid metabolism between clinical hyperandr
作者
陈丽
郝丽娟
CHEN Li;HAO Li-juan(Department of Obstetrics and Gynecology,Women and Children’s Hospital of Chongqing Medical University)
出处
《医学信息》
2022年第12期113-117,共5页
Journal of Medical Information
基金
重庆市基础研究与前沿探索项目(重庆市自然科学基金)(编号:cstc2018jcyjAX0648)。
关键词
多囊卵巢综合征
腹型肥胖
高雄
脂代谢异常
胰岛素抵抗
腰围
Polycystic ovary syndrome
Abdominal obesity
hyperandrogenism
Lipid metabolism disorder
Insulin resistance
Waist circumference
