摘要
目的 探讨蒙药验方《亚日饮汤》提取物对H37RV感染小鼠血清IL-12的影响。方法 通过气溶胶建立H37RV感染小鼠模型,设空白组、模型组、异烟肼组、亚日饮汤高、中、低剂量组,治疗28天后,处死小鼠后用ELISA方法测定小鼠血清中IL-12水平,结果 模型组、亚日饮汤高、中、低剂量组的水平高于空白组、异烟肼组(P<0.05),亚日饮汤高、中、低剂量组的水平高于模型组(P<0.05)。结论 亚日饮汤可以提高H37RV感染小鼠模型血清中的IL-12水平,可能是该药治疗结核病机制之一。
Objective To study the effect of Yariyintang extract on serum IL-12of mice infected with H37RV.Methods The mice model of H37RV infection was established by aerosol,including blank group,model group,isoniazid group,Yariyintang high-dose,medium-dose and low-dose groups.After 28days of treatment,the mice were killed and the serum IL-12level was determined by ELISA method.Results The levels of model group,high-dose,medium-dose and low-dose groups of Yariyintang were higher than those in blank group and isoniazid group(P<0.05),the levels of high-dose,medium-dose and low-dose groups of Yariyintang were higher than those in model group(P<0.05).Conclusion Yariyintang can increase the level of IFN-γin serum of H37RV infected mice,which may be one of the mechanisms of Yariyintang in the treatment of tuberculosis.
作者
布仁特古斯
陆宇
马媛媛
照娜
乌日古玛拉
图门乌力吉
BUREN Tegus;LU Yu;MA Yuan-yuan(School of Mongolian Medicine,Inmer Mongolia Medical University,Hohhot 010010,China)
出处
《中国实验诊断学》
2022年第3期422-424,共3页
Chinese Journal of Laboratory Diagnosis
基金
国家自然科学基金资助项目(81460717)。
