摘要
背景:半月板损伤对膝骨关节影响的研究多集中在胫股关节间室,国外有半月板外突与髌股关节骨关节炎相关性报道,但国内相关研究较少。目的:基于骨关节炎倡议数据库(OAI)的公开数据,以MRI半定量评分评价半月板外突与髌股关节骨关节炎的相关性。方法:数据库中选取在基线时有完整MRI膝骨关节炎评分以及其他临床信息完整的参与者共1109人作为研究对象。采用MRI膝骨关节炎评分系统对研究对象的半月板撕裂、浸渍、外突以及髌股关节软骨、骨髓病变进行评分,采用问卷等方法采集了参与者的性别、年龄、种族、体质量指数、膝关节受伤史、手术史等信息。使用Logistic回归分析确定半月板外突与髌股关节骨关节炎的关系。结果与结论:①横断面研究显示,内、外侧半月板外突人群在内、外侧髌股关节中易发生软骨及全层软骨损伤和骨髓病变;②Logistics回归分析在调整混杂因素后(调整模型2),内侧半月板外突与内侧髌股关节任何软骨损伤[OR:2.4(95%CI:1.6,3.6)]、全层软骨损伤[OR:1.5(95%CI:1.0,2.1)]呈正相关,在未调整[OR:0.8(95%CI:0.6,1.1)]与调整混杂因素后[OR:1.3(95%CI:0.9,1.8)]内侧半月板外突与内侧髌股关节骨髓病变均无相关性;③在调整混杂因素后(调整模型2),外侧半月板外突与外侧髌股关节任何软骨损伤[OR:2.1(95%CI:1.0,4.5)]、全层软骨损伤[OR:2.3(95%CI:1.1,4.6)]呈正相关,在未调整混杂因素时[OR:1.7(95%CI:1.0,2.9)],外侧半月板外突与外侧髌股关节骨髓病变呈正相关,在调整混杂因素后[OR:1.1(95%CI:0.6,2.1)]两者无相关;④基于骨关节炎倡议数据库(OAI)的公开数据,分析结果显示美国人群中半月板外突与髌股关节软骨损伤呈正相关。
BACKGROUND:The research on the effect of meniscus injury on knee osteoarthritis is mostly concentrated in the tibiofemoral compartment.There are reports on the correlation between meniscus extrusion and patellofemoral osteoarthritis outside China,but there are few related studies in China.OBJECTIVE:To explore the association between meniscus extrusion and patellofemoral osteoarthritis based on published data from the Osteoarthritis Initiative.METHODS:Totally 1109 participants with complete MRI Osteoarthritis Knee Score and other clinical information at baseline were selected.Meniscal tear,maceration,extrusion,patellofemoral cartilage and bone marrow lesions were scored by MRI Osteoarthritis Knee Score semi-quantitative scoring system.Gender,age,race,body mass index,history of knee injury,and history of surgery were collected by questionnaire.Logistic regression analysis was used to determine the relationship between meniscal extrusion and patellofemoral osteoarthritis.RESULTS AND CONCLUSION:(1)The cross-sectional study showed that patients with medial and lateral meniscus extrusion had a high incidence of any cartilage injury,full-thickness cartilage injury,and bone marrow lesions in medial and lateral patellofemoral joint.(2)Logistic regression analysis showed that after adjusting for confounding factors(adjustment model 2),the medial meniscus extrusion was positively correlated with any cartilage injury of the medial patellofemoral joint[OR:2.4(95%CI:1.6,3.6)]and full-thickness cartilage injury[OR:1.5(95%CI:1.0,2.1)];there was no correlation between medial meniscus extrusion and medial patellofemoral joint bone marrow lesions without adjustment[OR:0.8(95%CI:0.6,1.1)]and after adjustment for confounding factors[OR:1.3(95%CI:0.9,1.8)].(3)After adjusting for confounding factors(adjustment model 2),lateral meniscus extrusion was positively correlated with any cartilage injury of the lateral patellofemoral joint[OR:2.1(95%CI:1.0,4.5)]and full-thickness cartilage injury[OR:2.3(95%CI:1.1,4.6)];while without adjusting
作者
郭颖奇
宫先旭
张岩
肖寒
王野
谷文光
Guo Yingqi;Gong Xianxu;Zhang Yan;Xiao Han;Wang Ye;Gu Wenguang(Department of Traumatic Orthopedics,The First Affiliated Hospital of Harbin Medical University,Harbin 150001,Heilongjiang Province,China)
出处
《中国组织工程研究》
CAS
北大核心
2023年第4期600-605,共6页
Chinese Journal of Tissue Engineering Research
关键词
半月板外突
半月板损伤
髌股关节骨关节炎
膝关节骨关节炎
核磁共振
横断面研究
软骨损伤
meniscal extrusion
meniscus injury
patellofemoral osteoarthritis
knee osteoarthritis
magnetic resonance imaging
cross-sectional study
cartilage injury
