摘要
目的探讨不同孕周使用胰岛素对妊娠糖尿病(GDM)患者血糖控制情况及妊娠结局的影响。方法选取2020年7月—2021年6月该院收治的GDM患者82例为研究对象,根据使用胰岛素治疗时的孕周进行分组,其中孕周≥32周为对照组,孕周<32周为研究组,每组41例。对比两组治疗前与分娩时的血糖指标、妊娠结局与新生儿结局进行。结果分娩时,两组餐后2 h血糖与空腹血糖指标对比,差异无统计学意义(t=0.395、1.168,P>0.05)。两组剖宫产、妊娠高血压发生率对比,差异无统计学意义(χ^(2)=0.201、0.263,P>0.05);研究组早产、羊水过多、宫内窘迫发生率低于对照组,差异有统计学意义(χ^(2)=4.493、5.145、4.493,P<0.05)。两组新生儿低血糖、新生儿窒息发生率对比,差异无统计学意义(χ^(2)=0.852、0.263,P>0.05);研究组巨大儿发生率低于对照组,差异有统计学意义(χ^(2)=4.493,P<0.05)。结论不同孕周使用胰岛素治疗GDM对于血糖的控制效果相当,但早期使用胰岛素能够有效改善妊娠结局,降低巨大儿的发生率。
Objective To investigate the effect of insulin use at different gestational weeks on blood glucose control and pregnancy outcomes in patients with gestational diabetes mellitus(GDM).Methods Eighty-two study subjects were all GDM patients admitted to the hospital from July 2020 to June 2021 as the study objects,and they were divided into groups according to the gestational age of insulin therapy.The gestational age≥32 weeks was the control group,and the gestational age<32 weeks was the study group,with 41 cases in each group.The blood glucose indexes,pregnancy outcomes and neonatal outcomes were compared between the two groups before treatment and during delivery.Results During delivery,there was no statistically significant difference in 2 h postprandial blood glucose and fasting blood glucose between the two groups(t=0.395,1.168,P>0.05),there was no statistically significant difference in the comparison of the incidence of cesarean section and pregnancy-induced hypertension between the two groups(χ^(2)=0.201,0.263,P>0.05).The incidences of premature birth,polyhydramnios and intrauterine distress in the study group were lower than those in the control group,the difference was statistically significant(χ^(2)=4.493,5.145,4.493,P<0.05).There was no statistically significant difference between the two groups in the incidence of neonatal hypoglycemia and neonatal asphyxia(χ^(2)=0.852,0.263,P>0.05).The incidence of macrosomia in the study group was lower than that in the control group,the difference was statistically significant(χ^(2)=4.493,P<0.05).Conclusion The effect of insulin therapy on GDM in different gestational weeks is similar in blood glucose control,but early use of insulin can effectively improve pregnancy outcomes and reduce the incidence of macrosomia.
作者
武红
WU Hong(Department of Obstetrics,Xintai People's Hospital,Xintai,Shandong Province,271200 China)
出处
《糖尿病新世界》
2022年第9期90-93,共4页
Diabetes New World Magazine
关键词
孕周
胰岛素
妊娠糖尿病
血糖
妊娠结局
Gestational age
Insulin
Gestational diabetes
Blood glucose
Pregnancy outcome
