摘要
目的分析甲型流感合并非单纯性上呼吸道感染的影响因素。方法回顾性分析2019年9月至2020年9月本院收治的214例甲型流感患儿的临床资料,根据是否合并其他系统疾病将患儿分为单纯性上呼吸道感染组(n=37)和非单纯性上呼吸道感染组(n=177)。采用单因素分析及多因素Logistic回归分析探讨甲型流感合并非单纯性上呼吸道感染的影响因素。分析淋巴细胞计数、C反应蛋白(CRP)对甲型流感合并非单纯性上呼吸道感染的预测价值。结果单因素分析结果显示,两组的淋巴细胞计数、CRP、痰细菌培养、肺炎支原体抗体IgM比较,差异具有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,淋巴细胞计数、CRP、痰细菌培养、肺炎支原体抗体IgM是甲型流感合并非单纯性上呼吸道感染的危险因素(P<0.05)。淋巴细胞计数预测甲型流感合并非单纯性上呼吸道感染的ROC曲线下面积为0.749(P=0.000),最佳临界值为2.560×109/L,灵敏度为59.500%,特异度为81.400%;CRP预测甲型流感合并非单纯性上呼吸道感染的ROC曲线下面积为0.736(P=0.000),最佳临界值为11.270 mg/L,灵敏度为70.300%,特异度为74.000%。结论淋巴细胞计数、CRP、痰细菌培养、肺炎支原体抗体IgM是甲型流感合并非单纯性上呼吸道感染的危险因素。
Objective To analyze the influencing factors of influenza A combined with non-simple upper respiratory tract infection.Methods The clinical data of 214 children with influenza A treated in our hospital from September 2019 to September 2020 were analyzed retrospectively.The children were divided into simple upper respiratory tract infection group(n=37)and non-simple upper respiratory tract infection group(n=177)according to whether combined with other systemic diseases.Univariate analysis and multivariate Logistic regression analysis were used to explore the influencing factors of influenza A combined with non-simple upper respiratory tract infection.The predictive values of lymphocyte count and C-reactive protein(CRP)on influenza A combined with non-simple upper respiratory tract infection were analyzed.Results Univariate analysis results showed that there were significant differences in lymphocyte count,CRP,sputum bacterial culture and Mycoplasma pneumoniae antibody IgM between the two groups(P<0.05).Multivariate Logistic regression analysis results showed that lymphocyte count,CRP,sputum bacterial culture and Mycoplasma pneumoniae antibody IgM were the risk factors for influenza A combined with non-simple upper respiratory tract infection(P<0.05).The area under ROC curve of influenza A combined with non-simple upper respiratory tract infection predicted by lymphocyte count was 0.749(P=0.000),the best critical value was 2.560×109/L,the sensitivity was 59.500%,and the specificity was 81.400%;the area under ROC curve of influenza A combined with non-simple upper respiratory tract infection predicted by CRP was 0.736(P=0.000),the best critical value was 11.270 mg/L,the sensitivity was 70.300%,and the specificity was 74.000%.Conclusion Lymphocyte count,CRP,sputum bacterial culture and Mycoplasma pneumoniae antibody IgM are the risk factors for influenza A combined with non-simple upper respiratory tract infection.
作者
刘莎莎
涂阳阳
孙明
张乐
LIU Shasha;TU Yangyang;SUN Ming;ZHANG Le(Pediatrics Department,Hanzhong Central Hospital,Hanzhong 723000,China)
出处
《临床医学研究与实践》
2022年第17期23-26,共4页
Clinical Research and Practice
关键词
甲型流感
单纯性上呼吸道感染
儿童
实验室检查指标
influenza A
simple upper respiratory tract infection
children
laboratory inspection index
