摘要
目的:研究血清白细胞介素-6(IL-6)和细胞间黏附分子-1(ICAM-1)对急性胰腺炎严重程度的早期判断价值。方法:收集临床确诊的28例急性胰腺炎(AP)患者,分为重症急性胰腺炎(SAP)13例和轻症急性胰腺炎(MAP)15例两组,另选择10例体检健康人群作对照组(CG),分别测定血清IL-6和ICAM-1的浓度、并进行比较。结果:(1)发病24h内入院的SAP患者血清IL-6和ICAM-1浓度与MAP患者及对照组之间有显著性差异(P<0.01);而MAP患者与CG之间无显著性差异(P>0.05)(2)入院时SAP患者血清IL-6浓度与MAP患者及对照组之间有明显差异(P<0.01);入院后SAP患者的血清IL-6浓度逐渐下降,5d后与MAP比较无显著性差异(P>0.05)。(3)入院2d后SAP患者血清ICAM-1的浓度升高最明显,以后逐渐下降,但与MAP比较均有显著性差异(P<0.05)。讨论:血清IL-6和ICAM-1对急性胰腺炎病情严重程度有早期判断价值。
Objective：Through testing the blood serum IL-6 and ICAM-1, estimating their early judgement value to severity of acute pancreatitis. Methods：To test and compare the blood serum IL-6 and ICAM-1 concentration of 28 cases who were diagnosed acute pancrea- tiffs （severe acute pancreatitis 13 cases, mild acute pancreatitis 15 cases） and 10 cases as health control group. Results： （1） Serum IL-6 and ICAM-1 concentration of SAP patients who hospitalized within 24 h had significant difference with MAP and CG（P〈0. 01） . but the concentration of MAP had not significant difference with CG（P〈0. 05）. （2） Serum IL-6 concentration of SAP patients who hospitalized within 24 h had significant difference with MAP and CG （P^0. 01） ; but the concentration decreases after admission, there was not significant de- viation comparing with MAP in the fifth day（P^0.05）. （3） In the second day of admission, serum ICAM-1 concentration of SAP patients increased most obviously, and had still significant deviation comparing with MAP（P〈0. 05）. Conclusions：The serum IL-6 and ICAM-1 concentration has early judgement value to severity of acute pancreatitis.
出处
《国际消化病杂志》
CAS
2007年第4期303-305,共3页
International Journal of Digestive Diseases
