摘要
抑郁症是一种与现代生活密切相关的常见的精神疾病,其发病率逐年上升,现有的精神健康资源存在一些不足,使得抑郁症的识别率较低、病程较长、复发率较高。儿童青少年、孕产妇、老年人等都有可能患抑郁症,不同人群抑郁症的发病原因各异,表现有所不同,在临床诊断和治疗过程中,抗抑郁药物的干预也存在一定的风险。最新的研究表明,作为一种人体生命活动必需的水溶性维生素——叶酸的缺乏,不仅可以导致胚胎期胎儿的神经管发育异常,而且还可能与抑郁症等神经精神系统疾病有关。而通过补充叶酸(特别是活性叶酸)对改善抑郁状态,调节神经递质具有一定的辅助治疗作用。针对这一发现,本文对不同人群的抑郁症特点和叶酸干预作一综述,旨在揭示叶酸在不同人群抑郁症中可能发挥的作用,为抑郁症的治疗提供一种新的思路。
Depression is a common mental disease that′s closely related to modern life,and its incidence is increasing year by year,and the existing mental health resources have some deficiencies so that the identification rate of depression is low,the disease duration is long,and the recurrence rate is high.Children and adolescents,pregnant women,older adults are at risk for depression,the onset and presentation of depression vary among different populations,and there are risks associated with antidepressant drug interventions during clinical diagnosis and treatment.The latest research shows that the deficiency of folic acid,a water-soluble vitamin,that is essential for human life activities,not only leads to abnormal neural tube development in the fetus during the embryonic period,but may also be associated with neuropsychiatric disorders such as depression.While supplementation of folic acid(especially active folate)for improving depression status and regulating neurotransmitters has a certain adjuvant therapeutic effect.In response to this finding,this paper provides a review of depression characteristics and folic acid interventions in different populations,the aim of this paper reveals the possible role of folic acid in depression in different populations and provides a new way of thinking for the treatment of depression.
作者
薛娟
马文斌
涂华
顾睿
刘康
成永之
连增林
XUE Juan;MA Wenbin;TU Hua;GU Rui;LIU Kang;CHENG Yongzhi;LIAN Zenglin(Department of Research and Development,Beijing Jinkang Hexin Pharmaceutical Technology Co.,Ltd,Beijing 100176,China;Department of Research and Development,Lianyungang Jinkang Hexin Pharmaceutical Co.,Ltd,Jiangsu Province,Lianyungang 222000,China)
出处
《中国当代医药》
CAS
2022年第16期53-56,共4页
China Modern Medicine
关键词
抑郁症
不同人群
活性叶酸
亚甲基四氢叶酸还原酶
关联性
Depression
Different groups of people
Active folate
Methylenetetrahydrofolate reductase
Relevance
