摘要
目的:探讨影响应用万古霉素患者肾功能的相关因素。方法:回顾分析鄂尔多斯市中心医院2015-01~2021-01收治的使用万古霉素且进行血药浓度监测的143例住院患者的临床资料,Logistic分析给药剂量、年龄、血肌酐、血药谷浓度等与肾功能损伤的相关性。结果:143例患者中,26例患者用药后出现急性肾损伤,发生率为18.2%(26/143)。在多变量分析中万古霉素的用药剂量(P<0.05)、血药谷浓度(>20mg/L,P<0.05)、基线血清肌酐水平(P<0.05)是万古霉素血药低谷浓度的独立相关因素。结论:患者使用万古霉素出现肾功能损伤与给药剂量、基线血清肌酐、血药谷浓度显著相关,用药时需仔细评估个体化给药。
Objective:To explore the related factors affecting renal function in patients treated with vancomycin.Methods:The clinical data of 143 inpatients who used vancomycin and monitored the blood concentration in Ordos Central Hospital from January 2015 to January 2021 were retrospectively analyzed.Logistic analysis was used to analyze the correlation between dosage,age,blood creatinine,blood Valley concentration and renal function injury.Results:Among 143 patients,26 patients had acute renal injury after medication,and the incidence rate was 18.2%(26/143).In multivariate analysis,the dosage of vancomycin(P<0.05),blood trough concentration(P<0.05)and baseline serum creatinine level(P<0.05)were independent related factors of vancomycin blood trough concentration.Conclusions:The renal function impairment of patients using vancomycin is significantly related to the patient's dosage,baseline serum creatinine,and blood trough concentration.The individualized administration should be carefully evaluated.
作者
韩程程
苏长海
解沛涛
HAN Chengcheng;SU Changhai;XIE Peitao(Department of Pharmacy,Ordos Central Hospital,Ordos 017000 China)
出处
《疾病监测与控制》
2022年第1期11-14,共4页
Journal of Diseases Monitor and Control
关键词
万古霉素
血药浓度
急性肾损伤
vancomycin
blood concentration
acute kidney injury
