摘要
目的:探讨涎液化糖链抗原(KL-6)、基质金属蛋白酶-7(MMP-7)和透明质酸(HA)联合诊断结缔组织病合并间质性肺疾病(ILD)的价值。方法:选取2017年12月至2019年12月本院收治的69例结缔组织病合并ILD患者作为本文研究对象(合并ILD组),以单纯结缔组织病患者67例,同期体检的60例健康受试者分别作为单纯结缔组织病组和对照组。比较三组受试者血清KL-6、MMP-7和HA,Logistic回归分析确定结缔组织病发生ILD的独立影响因素,通过受试者工作特征(ROC)曲线分析诊断效能。结果:三组血清KL-6、MMP-7和HA水平有差异(P<0.05),合并ILD组患者血清KL-6、MMP-7和HA水平明显高于单纯结缔组织病组和对照组(P<0.05),单纯结缔组织病组患者血清KL-6、MMP-7和HA水平明显高于对照组(P<0.05)。Logistic回归分析结果表明,血清KL-6、MMP-7、HA等三指标及粉尘接触史均是结缔组织病发生ILD的显著影响因素(P<0.05)。ROC分析显示:血清KL-6、MMP-7和HA等三指标诊断结缔组织病发生ILD的AUC (0.95CI)分别为0.715 (0.439~0.988)、0.702 (0.440~0.959)、0.711(0.500~0.919),三指标联合应用的AUC(0.95CI)为0.811(0.705~0.913),诊断效能较高。结论:结缔组织病合并ILD患者血清KL-6、MMP-7及HA升高,联合应用诊断可提高对ILD的诊断效能,为早期诊断ILD提供一定的参考。
Objective: To investigate the value of joint diagnosis of connective tissue disease combined with interstitial lung disease(ILD) with krebs von den lungen-6(KL-6), matrix metalloproteinase-7(MMP-7) and hyaluronic acid(HA). Methods: A total of69 patients with connective tissue disease combined with ILD treated in our hospital from December 2017 to December 2019 were selected as the research object(combined ILD group), 67 patients with simple connective tissue disease and 60 healthy subjects who underwent physical examination in the same period were selected as the simple connective tissue disease group and the control group respectively. The serum KL-6, MMP-7 and HA of the three groups were compared, logistic regression analysis was used to determine the independent influencing factors of ILD in connective tissue disease, receiver operating characteristic(ROC) curve was used to analyze the diagnostic efficacy. Results: There was statistical significant difference in the levels of serum KL-6, MMP-7 and HA among the three groups(P<0.05), the levels of serum KL-6, MMP-7 and HA in the combined ILD group were significantly higher than those in the simple connective tissue disease group and the control group(P<0.05), the levels of serum KL-6, MMP-7 and HA in the simple connective tissue disease group were significantly higher than those in the control group(P<0.05). Logistic regression analysis showed that serum KL-6,MMP-7, HA and dust exposure history were significant influencing factors of ILD in connective tissue disease(P<0.05). ROC curve analysis showed that the AUC(95%CI)of serum KL-6, MMP-7 and HA for ILD in connective tissue disease were 0.715(0.439~0.988),0.702(0.440~0.959), 0.711(0.500~0.919) respectively, the AUC(95%CI) of the joint detection of the above three indexes was 0.811(0.705~0.913), which meant higher diagnostic efficiency. Conclusion: The levels of serum KL-6, MMP-7 and HA in patients with connective tissue disease combined with ILD increase, the joint diagnosis can improve the diagnostic efficienc
作者
苏菁
杨雅婷
贾聚娟
项保利
钱海红
支学军
李琛
赵建清
冯亚娆
SU Jing;YANG Ya-ting;JIA Ju-juan;XIANG Bao-li;QIAN Hai-hong;ZHI Xue-jun;LI Chen;ZHAO Jian-qing;FENG Ya-rao(Department of Respiratory and Critical Care Medicine,The First Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei,075000,China;Department of Rheumatology and Immunology,The First Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei,075000,China)
出处
《现代生物医学进展》
CAS
2022年第8期1534-1538,共5页
Progress in Modern Biomedicine
基金
河北省张家口市科技攻关计划项目(1921051D)
河北省重点课题计划项目(20160366)。
关键词
涎液化糖链抗原
基质金属蛋白酶-7
透明质酸
结缔组织病
间质性肺疾病
诊断价值
Krebs von den lungen-6
Matrix metalloproteinase-7
Hyaluronic acid
Connective tissue disease
Interstitial lung disease
Diagnosis value
