摘要
目的探究乳腺浸润性导管癌中分子标志物表达与病理诊断结果。方法回顾性分析凤冈县人民医院2015年1月—2020年12月收治的60例乳腺浸润性导管癌患者临床资料,并收集其病理组织标本,以免疫组化法检测其样本中分子标志物[雌激素受体(ER)、孕激素受体(PR)、人表皮生长因子受体(HER-2)、Ki-67]水平,并分析分子标志物与患者病理诊断之间的关系。结果年龄、组织学分级、TNM分级、肿瘤大小、是否存在腋窝淋巴结转移、腋窝转移淋巴结大小、是否复发,ER、PR阳性率比较,差异无统计学意义(P>0.05);组织学Ⅲ级HER-2阳性占比较Ⅰ~Ⅱ级高(60.87%vs 27.03%),存在腋窝淋巴结转移HER-2阳性占比较无腋窝淋巴结转移高(72.22%vs 26.19%),复发患者HER-2阳性较无复发转移高(75.00%vs 34.62%),差异有统计学意义(χ^(2)=6.769、11.124、4.712,P<0.05);TNM分期中Ⅲ~Ⅳ级Ki-67分级占比较Ⅰ~Ⅱ高(76.00%vs 40.00%),复发转移患者Ki-67阳性较无复发转移高(87.50%vs 50.00%),差异有统计学意义(χ^(2)=7.636、3.939,P<0.05)。结论ER、PR对乳腺浸润性导管癌病理诊断结果及预后无明显影响,HER-2、Ki-67对肿瘤组织学分期、TNM分期、是否存在腋窝淋巴结转移有影响。
Objective To explore the results of molecular markers expression and the results of pathological diagnosis in invasive ductal carcinoma of mammary glands.Methods The clinical data of 60 patients with invasive ductal carcinoma of mammary glands admitted to People's Hospital of Fenggang County from January 2015 to December 2020 were retrospectively analyzed,and their pathological tissue samples were collected to detect molecular markers[estrogen receptor(ER),progesterone receptor(PR),human epidermal growth factor receptor(HER-2),Ki-67]levels in their samples by immunohistochemistry.Analyze the correlation between molecular markers and pathological diagnosis of patients.Results There was no statistically significant difference in the positive rates of ER and PR in age,histological grade,TNM grade,tumor size,whether there was axillary lymph node metastasis,axillary metastatic hymph node size,and whether there was recurrence(P>0.05).The proportion of HER-2 positive of histological gradeⅢwas higher than that of gradesⅠtoⅡ(60.87%vs 27.03%),and the proportion of HER-2 positive with axillary lymph node metastasis was higher than that without axillary lymph node metastasis(72.22%vs 26.19%),the proportion of HER-2 positive of recurrent patients was higher than those without recurrence and metastasis(75.00%vs 34.62%),and the difference was statistically significant(χ^(2)=6.769,11.124,4.712,P<0.05).The proportion of Ki-67 of TNM stage gradesⅢtoⅣwas higher than that of TNM stage gradesⅠtoⅡ(76.00%vs 40.00%),the positive rate of Ki-67 of patients with recurrence and metastasis was higher than that without recurrence and metastasis(87.50%vs 50.00%),and the difference was statistically significant(χ^(2)=7.636,3.939,P<0.05).Conclusion ER and PR have no significant effect on the pathological diagnosis result and prognosis of invasive ductal carcinoma of mammary glands.HER-2 and Ki-67 have effects on tumor histological stage,TNM stage,and the presence of axillary lymph node metastasis.
作者
李永琳
安仕勇
张培亮
蔡世远
刘黔明
LI Yonglin;AN Shiyong;ZHANG Peiliang;CAI Shiyuan;LIU Qianming(Department of Pathology,People's Hospital of Fenggang County,Zunyi,Guizhou Province,564200 China)
出处
《系统医学》
2022年第8期11-15,共5页
Systems Medicine
基金
贵州省卫生健康委科学技术基金项目(gzwkj2021-372)。
关键词
乳腺浸润性导管癌
分子标志物
病理诊断
Invasive ductal carcinoma of mammary glands
Molecular markers
Pathological diagnosis
