摘要
目的:观察脑复聪方联合尼莫地平治疗脑小血管病合并认知功能障碍的临床疗效。方法:122例脑小血管病合并认知功能障碍患者按照随机数字表法随机分为对照组62例和观察组60例。对照组给予基础治疗及尼莫地平,观察组在对照组治疗基础上给予脑复聪方治疗,共治疗3个月。治疗后,比较两组患者临床疗效及安全性,治疗前后中医证候积分、蒙特利尔认知评估量表(Montreal cognitive assessment Scale,MoCA)评分、简易精神状态量表(mental state scale,MMSE)评分、日常生活能力量表(ability of daily living scale,ADL)评分,比较两组治疗前后血清S100β、白细胞介素-8(interleukin-8,IL-8)水平。结果:治疗后,观察组有效率(95.00%)显著高于对照组(80.65%)(P<0.05);两组患者中医证候积分均高于本组治疗前(P<0.05),且观察组中医证候积分均高于同期对照组(P<0.05);两组患者MoCA评分各维度得分及总分均高于本组治疗前,且观察组高于同期对照组(P<0.05);两组患者MMSE评分各维度得分及总分、ADL评分均显著高于治疗前,且观察组高于同期对照组(P<0.05);两组患者血清S100β、IL-8水平显著低于本组治疗前,且观察组低于同期对照组(P<0.05)。治疗期间两组患者血尿常规、心电图及肝肾功能检查均未出现明显异常。结论:脑复聪方联合尼莫地平治疗脑小血管病合并认知功能障碍疗效显著,能显著改善患者认知功能及自理能力,减轻脑损伤程度,且安全性较高。
Objective:To observe the clinical efficacy of Naofucong Recipe combined with nimodipine in treatment of cerebral small vessel disease complicated with cognitive dysfunction.Methods:A total of 122 patients with cerebral small vessel disease complicated with cognitive impairment were randomly divided into the control group of 62 cases and the observation group of 60 cases according to the random number table method.The control group was given basic treatment and nimodipine,and the observation group was given Naofucong prescription based on the treatment of the control group for a total of 3 months.After treatment,the clinical efficacy and safety of the two groups of patients were compared,and the scores of TCM syndromes,Montreal cognitive assessment Scale(MoCA)score,simple mental state scale(MMSE)score before and after treatment,daily The ability of daily living scale(ADL)score was used to compare the levels of serum S100βand interleukin-8(IL-8)between the two groups before and after treatment.Results:After treatment,the effective rate(95.00%)of the observation group was significantly higher than that of the control group(80.65%)(P<0.05);the TCM syndrome scores of the two groups were higher than those before treatment(P<0.05);The TCM syndrome scores in the two groups were higher than those in the control group at the same period(P<0.05);the MoCA scores in each dimension and the total score in the two groups were higher than those before treatment in the same group,and the observation group was higher than the control group at the same period(P<0.05);The scores of each dimension of MMSE score,total score and ADL score in the two groups were significantly higher than those before treatment,and the observation group was higher than the control group at the same period(P<0.05);the serum S100βand IL-8 levels in the two groups were significantly lower than those in the same group Before treatment,the observation group was lower than the control group at the same period(P<0.05).During the treatment period,there were no
作者
栗洪娟
李艳
孙金玥
LI Hongjuan;LI Yan;SUN Jinyue(Dezhou Hospital of Traditional Chinese Medicine,Dezhou Shandong China 253000)
出处
《中医学报》
CAS
2022年第7期1524-1529,共6页
Acta Chinese Medicine
基金
山东省中医药科技发展计划项目(2019-0865)。
