摘要
目的应用磁共振扩散峰度成像(diffusion kurtosis imaging,DKI)技术,探究脑卒中后运动性失语症的脑微结构。方法选取2021年1月~2021年7月就诊于新疆医科大学第一附属医院,首发缺血性脑卒中引起的运动性失语症病例20例,纳入病例组;选取基本信息一致的健康志愿者20例,作为正常对照组,进行头颅平扫及DKI序列扫描,对DKI后处理,获得两组平均峰度(mean kurtosis,MK)、轴向峰度(axial kurtosis,AK)、径向峰度(radial kurtosis,RK)、各向异性分数(fractional anisotropy,FA)、平均扩散率(mean diffusion,MD)及纤维束走行图进行对比。结果病例组左侧Broca脑区MK、AK、RK值(分别为1.056±0.043、0.961±0.080、1.100±0.160)较对侧镜像区域MK、AK、RK值(分别为0.809±0.041、0.743±0.041、0.811±0.098)升高(P值均<0.01),差异有统计学意义;病例组左侧Broca脑区MK、AK、RK值(分别为1.056±0.043、0.961±0.080、1.100±0.160)较正常对照组左侧Broca脑区MK、AK、RK值(分别为0.763±0.044、0.788±0.029、0.781±0.015)升高(P值均<0.01),差异有统计学意义;病例组左侧Broca脑区FA、MD值(分别为0.085±0.030、0.884±0.145)较对侧镜像区域FA、MD值(分别为0.179±0.023、1.163±0.116)降低(P值均<0.01),差异有统计学意义;病例组左侧Broca脑区FA、MD值(分别为0.085±0.030、0.884±0.145)较正常对照组左侧Broca脑区FA、MD值(分别为0.194±0.009、1.082±0.055)降低(P值均<0.01),差异有统计学意义。结论DKI技术可无创、定量的显示患者脑微结构的异常变化,能给临床的治疗及康复理疗提供一定的理论依据。
Objective To explore the brain microstructure of motor aphasia caused by stroke by diffusion kurtosis imaging(DKI).Methods 20 cases of motor aphasia caused by ischemic stroke first diagnosed in the First Affiliated Hospital of Xinjiang Medical University from January 2021 to July 2021 were collected and included in the case group.20 healthy volunteers with roughly the same basic information were collected and included in the healthy control group.The head plain scan and DKI sequence scan were performed,and the original DKI images were post processed.The mean kurtosis(MK),axial kurtosis(AK),radial kurtosis(RK),fractional anisotropy(FA),mean diffusion(MD)and fiber bundle walk patterns were compared.ResultsIn the case group,the values of MK,AK and RK in the left Broca brain area(1.056±0.043,0.961±0.080 and 1.100±0.160,respectively)were significantly higher than those in the contralateral mirror image area(0.809±0.041,0.743±0.041 and 0.811±0.098,respectively)(P<0.01);The values of MK,AK and RK in the left Broca brain area of the case group(1.056±0.043,0.961±0.080 and 1.100±0.160 respectively)were significantly higher than those in the left Broca brain area of the normal control group(P<0.01);In the case group,the values of FA and MD in the left Broca brain area(0.085±0.030 and 0.884±0.145,respectively)were significantly lower than those in the contralateral mirror image area(0.179±0.023 and 1.163±0.116,respectively)(P<0.01);The values of FA and MD in the left Broca brain area of the case group(0.085±0.030 and 0.884±0.145,respectively)were significantly lower than those in the normal control group(0.194±0.009 and 1.082±0.055,respectively)(P<0.01).Conclusion DKI technology can non-invasively and quantitatively display abnormal changes in the brain microstructure of patients,and can provide a certain theoretical basis for clinical treatment and rehabilitation physiotherapy.
作者
叶彦池
黄海燕
成晓江
丁爽
王云玲
YE Yanchi;HUANG Haiyan;CHENG Xiaojiang;DING Shuang;WANG Yunling(Imaging Conter of The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830000, China)
出处
《医学影像学杂志》
2022年第5期721-725,共5页
Journal of Medical Imaging
基金
国家自然科学基金项目(编号:81860223)。
关键词
磁共振成像
运动性失语
扩散峰度成像
脑微结构
Magnetic resonance imaging
Motor aphasia
Diffusion kurtosis imaging
Brain microstructure
