摘要
目的观察三种他汀类药物治疗老年动脉粥样硬化性急性脑梗死(AACI)合并高血脂的临床效果。方法选取2019年1月-2020年12月天津市职业病防治院收治的65例老年AACI合并高血脂患者,采用随机数字表法分为辛伐他汀组(21例)、阿托伐他汀组(22例)、瑞舒伐他汀组(22例);分别给予辛伐他汀、阿托伐他汀、瑞舒伐他汀治疗,比较三组血脂水平[酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]、炎性因子[C反应蛋白(CRP)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)]、神经功能缺损评分(NIHSS)、肝功能[谷丙转氨酶(ALT)、谷草转氨酶(AST)]及不良反应。结果瑞舒伐他汀组TG、TC、LDL-C低于辛伐他汀组与阿托伐他汀组,HDL-C高于辛伐他汀组与阿托伐他汀组(P<0.05);三组CRP、IL-6、TNF-α水平及NIHSS评分均低于治疗前,且瑞舒伐他汀组低于辛伐他汀组与阿托伐他汀组(P<0.05);辛伐他汀组与阿托伐他汀组ALT、AST水平高于治疗前,且高于瑞舒伐他汀组(P<0.05);瑞舒伐他汀组治疗前后ALT、AST水平比较,差异无统计学意义(P>0.05);三组不良反应发生率比较,差异无统计学意义(P>0.05)。结论辛伐他汀、阿托伐他汀与瑞舒伐他汀三种他汀类药物均具有良好的降脂效果,可下调老年AACI合并高血脂患者的炎性反应,改善其神经功能,且不良反应少,其中瑞舒伐他汀的治疗效果及安全性最为理想。
Objective To observe the clinical effect of three statins in the treatment of elderly patients with atherosclerotic acute cerebral infarction(AACI)combined with hyperlipidemia.Methods A total of 65 elderly AACI patients with hyperlipidemia admitted to Tianjin Occupational Disease Precaution and Therapeutic Hospital from January 2019 to December 2020 were selected and randomly divided into simvastatin group(21 cases),atorvastatin group(22 cases)and rosuvastatin group(22 cases).Simvastatin,atorvastatin and rosuvastatin were given respectively.The blood lipid levels[triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)],inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)],neurological deficit score(NIHSS),liver function[alanine aminotransferase(ALT),aspartate aminotransferase(AST)]and adverse reactions were compared among the three groups.Results The levels of TG,TC and LDL-C in rosuvastatin group were lower than those in simvastatin group and atorvastatin group,and The level of HDL-C was higher than that in simvastatin group and atorvastatin group(P<0.05).The levels of CRP,IL-6,TNF-αand NIHSS scores in the three groups were lower than those before treatment,and those in the rosuvastatin group was lower than those in the simvastatin group and the atorvastatin group(P<0.05).The levels of ALT and AST in simvastatin group and atorvastatin group were higher than those before treatment,and higher than those in rosuvastatin group(P<0.05).There was no significant difference in ALT and AST levels before and after treatment in rosuvastatin group(P>0.05).There was no significant difference in the incidence of adverse reactions among the three groups(P>0.05).Conclusion Simvastatin,atorvastatin and rosuvastatin have good lipid-lowering effects,which can reduce the inflammatory response of elderly AACI patients with hyperlipidemia,improve their neurological function,and have few adverse reactions.Among them,rosu
作者
何丽
HE Li(Department of Physical Examination,Tianjin Occupational Disease Precaution and Therapeutic Hospital,Tianjin 300011,China)
出处
《医学信息》
2022年第11期150-153,共4页
Journal of Medical Information
