摘要
突触可塑性是神经可塑性的一种表现形式,在维持神经系统正常生理功能中起重要作用。对基因表达时间和空间上的精细调控是实现突触可塑性功能的重要因素之一,其中微RNA(miRNA)在基因转录后调控中发挥重要作用。miRNA与信使RNA的3′非翻译区结合,可稳定调节基因表达和翻译过程,并实现突触可塑性。一些特定miRNA在突触可塑性的调控中发挥着重要作用,如树突棘形态改变、微管动力学、长时程增强以及脑源性神经营养因子等,参与维持神经系统的正常生理功能。
Synaptic plasticity is a manifestation of neuroplasticity,which plays an important role in maintaining the normal nervous functions.The fine regulation of gene expression in time and space is one of the important factors to the function of synaptic plasticity,and microRNA(miRNA)plays an important role in the post-transcriptional regulation.MiRNA can stably regulate gene expression and translation process and achieve synaptic plasticity by combining with the 3′untranslated region of messenger RNA.Some specific miRNA play an important role in synaptic plasticity regulation,including the shape of dendritic spines,microtubule dynamics,long-term potentiation,brain-derived neurotrophic factor and so on,involved in maintaining the normal nervous functions.
作者
周芮
郝雷
王帆
ZHOU Rui;HAO Lei;WANG Fan(College of Basic Medical Sciences,Inner Mongolia Medical University,Hohhot 010110,China;Psychiatry Medicine Research Division,Beijing Huilongguan Hospital,Beijing 100096,China)
出处
《医学综述》
CAS
2022年第9期1685-1689,1694,共6页
Medical Recapitulate
基金
内蒙古自治区自然科学基金项目(2017MS0899)。
关键词
突触可塑性
微RNA
树突棘
长时程增强
脑源性神经营养因子
Synaptic plasticity
MicroRNA
Dendritic spine
Long-term potentiation
Brain-derived neurotrophic factor
