摘要
目的 探讨3.0 T动态增强磁共振成像(DCE-MRI)定量分析评价扶正消瘀散结方联合内分泌治疗Ⅲ、Ⅳ期前列腺癌的疗效,从微观角度证实和评价中医药的疗效,探讨可能的作用机制。方法 搜集2020年1月至2021年7月本院前列腺癌Ⅲ、Ⅳ期的患者60例,分为实验组30例采用扶正消瘀散结方联合内分泌治疗,对照组30例采用单纯内分泌治疗;采用DCE-MRI获取前列腺癌组织的微循环灌注的定量参数值,包括容积转运常数(K^(trans))、速率常数(K_(ep))、血管外细胞外间隙容积分数(V_(e))值,分别对两组治疗前、治疗后3个月的定量参数指标(K^(trans)、K_(ep)、V_(e))进行配对样本t检验,随后用两独立样本t检验进一步分析比较两组治疗前后各指标的差异。结果 两组患者治疗前的前列腺癌组织的K^(trans)、K_(ep)、V_(e)值无统计学差异(P>0.05);两组患者治疗前后对比,前列腺癌组织的微循环灌注的定量参数值K^(trans)、K_(ep)、V_(e)值有统计学差异(P<0.05),且治疗后各参数值均低于治疗前;治疗后3个月实验组与对照组前列腺癌组织的K^(trans)、K_(ep)、V_(e)值有统计学差异(P<0.05),且实验组各参数值均低于对照组。结论 两种治疗方法对晚期前列腺癌患者均有一定效果,通过DCE-MRI定量分析表明扶正消瘀散结方联合内分泌治疗的疗效高于单纯内分泌治疗。
Objective To investigate the efficacy of 3.0 T magnetic resonance dynamic contrast-enhanced MRI(DCE-MRI) quantitative analysis in evaluation of Fuzheng Xiaoyu Sanjie combined with endocrine treatment for Ⅲ and Ⅳ stage-prostate cancer.To confirm and evaluate the efficacy of Chinese medicine from a microscopic perspective and to explore the possible mechanism.Methods Sixty patients with prostate cancer of stage Ⅲ and Ⅳ in our hospital from January 2020 to July 2021 were collected,and divided into 30 cases in the experimental group,who were treated with the combination of endocrine therapy with Fuzheng Xiaoyu Sanjie,and 30 cases in the control group,who were treated with endocrine therapy;the quantitative parameter values of microcirculatory perfusion in prostate cancer tissues were obtained by dynamic contrast-enhanced MRI,including K^(trans)、K_(ep) and V_(e) Value.The quantitative parameters(K^(trans)、K_(ep)、V_(e)) were tested by paired samples t-test before and after 3 months of treatment in the two groups,followed by two independent samples t-test to further analyse and compare the differences between the two groups before and after treatment.Results The quantitative parameter of K^(trans)、K_(ep) and V_(e) Value in two groups show no significant difference before treatment between two groups(P>0.05).The values of K^(trans)、K_(ep) and V_(e) Value in all patients were significantly different after 3 months therapy(P<0.05),and all these values declined after the therapy(P<0.05).Those three values in the experimental group were significantly lower than those in the control group.Conclusion Both treatments are effective in patients with advanced prostate cancer,and the quantitative analysis by DCE-MRI showes that Fuzheng Xiaoyu Sanjie combinaed with endocrine therapy is more efficient than that of endocrine therapy alone.
作者
徐嬿
杨贤卫
王千里
李明睿
蔡德春
XU Yan;YANG Xianwei;WANG Qianli(Department of Radiology,The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou,Guangdong Province 510405,P.R.China)
出处
《临床放射学杂志》
北大核心
2022年第4期686-689,共4页
Journal of Clinical Radiology
基金
广东省中医药局科研项目(编号:20202051)。
关键词
前列腺癌
扶正消瘀散结
微循环
动态增强磁共振成像
Prostate cancer
Fuzhen Xiaoyu Sanjie
Microcirculation
Dynamic contrast-enhanced magnetic resonance imaging
