摘要
目的探讨化疗栓塞术联合微泡造影剂结合高强度聚焦超声治疗原发性肝癌患者血清游离三碘甲状腺原氨酸(FT_(3))、反三碘甲状腺原氨酸(rT_(3))、血管内皮生长因子(VEGF)水平变化及意义。方法选取2018年1月—2019年6月收治的原发性肝癌64例,根据患者治疗意愿非随机化分为对照组30例和观察组34例。对照组接受化疗栓塞术联合高强度聚焦超声治疗,观察组接受化疗栓塞术联合微泡造影剂结合高强度聚焦超声治疗。选取同期健康体检者30例设为健康组。比较肝癌组治疗前与健康组、观察组与对照组治疗前后血清FT_(3)、rT_(3)、VEGF水平,同时比较临床疗效、并发症及随访生存情况。结果观察组与对照组治疗总有效率比较差异无统计学意义(P>0.05)。肝癌组治疗前的血清FT_(3)水平低于健康组,血清rT_(3)、VEGF水平高于健康组(P<0.01)。与治疗前比较,观察组与对照组治疗后的血清FT_(3)水平明显升高,血清rT_(3)、VEGF水平明显降低(P<0.01)。观察组与对照组治疗后并发症发生率比较差异无统计学意义(P>0.05)。观察组中位生存期为11.5(7.2~20.6)个月,死亡22例,存活12例;对照组中位生存期为8.1(5.5~19.7)个月,死亡24例,存活6例。两组累积生存率比较差异有统计学意义(P<0.05)。结论化疗栓塞术联合微泡造影剂结合高强度聚焦超声治疗原发性肝癌可延长生存期。血清FT_(3)、rT_(3)、VEGF水平变化与患者预后相关。
Objective To investigate changes and significances of serum free triiodothyronine(FT_(3)),reverse triiodothyronine(rT_(3))and vascular endothelial growth factor(VEGF)in patients with primary liver cancer(PLC)treated by chemoembolization combined with microbubble contrast agent and high-intensity focused ultrasound(HIFU).Methods A total of 64 patients with PLC who had been treated between January 2018 and June 2019 were selected and divided into the control group(n=30)and observation group(n=34)according to the patients'treatment wills.Control group received chemoembolization combined with HIFU therapy,while observation group received chemoembolization combined with microbubble contrast agent and HIFU therapy.Thirty healthy peoples who had taken physical examinations at the same period were selected as healthy group.Serum levels of FT_(3),rT_(3) and VEGF were compared between liver cancer group before treatment and healthy group,and between observation group and control group before and after treatment,and clinical efficacy,incidence rates of complications and follow-up survival conditions were also compared.Results There was no statistically significant difference in the total effective rate between observation group and control group(P>0.05).In liver cancer group,serum FT_(3) level before treatment was significantly lower,while serum rT_(3) and VEGF levels were significantly higher than those in healthy group(P<0.01).Compared with those before treatment,serum levels of FT_(3) were significantly increased,while serum levels of rT_(3) and VEGF were significantly decreased after treatment in observation and control groups(P<0.01).There was no statistically significant difference in incidence rate of complications between observation and control groups after treatment(P>0.05).In observation group,the median survival time was 11.5(7.2-20.6)months,and 22 patients died and 12 patients survived.In control group,the median survival time was 8.1(5.5-19.7)months,and 24 patients died and 6 patients survived.There was a stat
作者
陈英
露娜
德钦
郑静
CHEN Ying;LU Na;DE Qin;ZHENG Jing(Department of Ultrasound,People's Hospital of Ganzi Tibetan Autonomous Prefecture,West China Hospital,Sichuan University,kangding,Sichuan 626000,China)
出处
《临床误诊误治》
CAS
2022年第5期51-55,共5页
Clinical Misdiagnosis & Mistherapy
基金
四川省医学科研课题计划项目(S2018249)。
