摘要
目的分析急性呼吸窘迫综合征(ARDS)并发急性肾损伤(AKI)的相关因素,探讨血管生成素2(Ang2)、C反应蛋白(CRP)与ARDS并发AKI的关系,分析Ang2和CRP的联合预测价值。方法选取2020年1月至2021年8月普宁市人民医院收治的80例ARDS患者作为研究对象进行回顾性分析,根据是否并发AKI将其分为观察组(24例,ARDS并发AKI)和对照组(56例,ARDS未并发AKI)。采用多因素Logistic回归分析ARDS并发AKI的相关因素,分析Ang2和CRP诊断ARDS并发AKI的价值。结果多因素Logistic分析结果显示,机械通气(95%CI=1.304~3.608,P=0.003,OR=2.169)、血浆Ang2(95%CI=1.623~3.305,P<0.05,OR=2.316)及血浆CRP(95%CI=1.203~7.049,P=0.018,OR=2.912)是ARDS并发AKI的高危因素。受试者工作曲线(ROC)分析显示,血浆Ang2(AUC=0.731,敏感度=0.833,特异度=0.500,P=0.022)、血浆CRP(AUC=0.747,敏感度=0.833,特异度=0.679,P=0.014)及联合预测(AUC=0.795,敏感度=0.917,特异度=0.607,P=0.003)诊断ARDS并发AKI风险具有较高准确性。结论Ang2、CRP与ARDS并发AKI相关,联合检测血浆Ang2和CRP有助于诊断ARDS并发AKI风险。
Objective To analyze the related factors of acute respiratory distress syndrome(ARDS)complicated with acute kidney injury(AKI),therelationship between angiopoietin 2(Ang2),C-reactive protein(CRP)andARDS complicated with AKI were explored,and the combined predictive value of Ang2 and CRP were analyzed.Methods The clinical datas of 80 patients with ARDS in Puning People’s Hospital from January 2020 to August 2021 were collected,the patients were divided into observation group(24 cases of ARDS complicated with AKI)and control group(56 cases of ARDS without AKI),which accorded to whether AKI was concurrent.Logistic multivariate analysis was used to analyze the related factors of ARDS complicated with AKI,and to analyze the value of Ang2 and CRP in judging ARDS complicated with AKI.Results Logistic multivariate analysis showed that mechanical ventilation(95%CI=1.304~3.608,P=0.003,OR=2.169),plasma Ang2(95%CI=1.623~3.305,P<0.05,OR=2.316)and plasma CRP(95%CI=1.203~7.049,P=0.018,OR=2.912)were the high risk factors of ARDS complicated with AKI.The receiver operating char-acteristic(ROC)analysis showed that plasma Ang2(AUC=0.731,sensitivity=0.833,specificity=0.500,P=0.022),plasma CRP(AUC=0.747,sensitivity=0.833,specificity=0.679,P=0.014)and joint prediction probability(AUC=0.795,sensitivity=0.917,specificity=0.607,P=0.003)had high accuracy in judging the risk of ARDS complicated with AKI.Conclusion Ang2 and CRP are related to the condition of ARDS complicated with AKI.The combined detection of plasma Ang2 and CRP is helpful to judge the risk of ARDS complicated with AKI.
作者
叶剑滨
叶剑清
钟超
YE Jianbin;YE Jianqing;ZHONG Chao(Department of Critical Care,Puning People’s Hospital,Jieyang,Guangdong 515300,China;Emergency Department,Puning Xiajiashan Town Health Center,Jieyang,Guangdong 515323,China;Department of Gastroenterology,Puning People’s Hospital,Jieyang,Guangdong 515300,China)
出处
《大医生》
2022年第9期12-15,共4页
Doctor
