摘要
背景:外周血检测是临床常规的检查项目,粒细胞和血小板常用于衡量炎症反应的严重程度,各种炎症指标的比值预测疾病预后值得探究。目的:比较并分析血小板与淋巴细胞比值(PLR)、中性粒细胞与淋巴细胞比值(NLR)、单核细胞与淋巴细胞比值(MLR)、红细胞分布宽度与血小板比值(RPR)、C反应蛋白与淋巴细胞比值(CLR)和C反应蛋白(CRP)评估高脂血症性急性胰腺炎(HLAP)严重程度的诊断效能。方法:回顾性收集2018年1月-2020年12月于郑州大学第一附属医院确诊的104例HLAP患者的临床和实验室资料,根据修订亚特兰大分类将患者分为轻度HLAP、中重度/重度HLAP。以同期44名健康人作为对照组。比较PLR、NLR、MLR、RPR、CLR、CRP水平,应用ROC曲线分析PLR、NLR、MLR、RPR、CLR、CRP诊断中重度/重度HLAP的效能。结果:HLAP组PLR、NLR、MLR、RPR、CLR、CRP均显著高于对照组(P <0.05);中重度/重度HLAP组PLR、NLR、MLR、RPR、CLR、CRP显著高于轻度HLAP组(P <0.05)。Cut-off值分别为220.48、10.95、0.84、0.12、76.66、87.44 mg/L、0.37时,PLR、NLR、MLR、RPR、CLR、CRP以及PLR、NLR、MLR、RPR、CLR联合诊断中重度/重度HLAP的敏感性分别为0.73、0.45、0.47、0.82、0.65、0.65、0.88,特异性分别为0.85、0.87、0.90、0.81、0.83、0.83、0.85,AUC分别为0.84、0.65、0.67、0.87、0.77、0.75、0.94。结论:PLR、NLR、MLR、RPR、CLR、CRP均能评估HLAP的严重程度,其中PLR、NLR、MLR、RPR、CLR联合诊断中重度/重度HLAP的敏感性较高、诊断效能较好。
Background: Peripheral blood test is a routine clinical examination item. Granulocytes and platelets are often used to measure the severity of inflammatory response,and it is worthy to investigate the value of various inflammatory indices ratio for predicting the prognosis of disease. Aims: To compare and analyze the diagnostic efficacy of platelet to lymphocyte ratio( PLR),neutrophil to lymphocyte ratio( NLR),monocyte to lymphocyte ratio( MLR),red blood cell distribution width to platelet ratio( RPR),C-reactive protein to lymphocyte ratio( CLR) and C-reactive protein( CRP) in evaluating the severity of hyperlipidemic acute pancreatitis( HLAP). Methods: The clinical and laboratory data of 104 patients with HLAP from January 2018 to December 2020 at the First Affiliated Hospital of Zhengzhou University were retrospectively analyzed. According to the revised Atlanta classification,HLAP patients were divided into mild HLAP,moderate to severe/severe HLAP. Forty-four healthy subjects during the same period were served as the controls. PLR,NLR,MLR,RPR,CLR and CRP were compared between HLAP group and control group. The ROC curve was used to analyze the diagnostic efficacy of PLR,NLR,MLR,RPR,CLR and CRP for the diagnosis of moderate to severe/severe HLAP. Results: PLR,NLR,MLR,RPR,CLR and CRP were significantly increased in HLAP group than in control group( P < 0. 05);PLR,NLR,MLR,RPR,CLR and CRP were significantly increased in moderate to severe/severe HLAP group than in mild HLAP group( P < 0. 05). The cut-off values of PLR,NLR,MLR,RPR,CLR,CRP and combined PLR,NLR,MLR,RPR,CLR were 220. 48,10. 95,0. 84,0. 12,76. 66,87. 44 mg/L,0. 37,respectively,the sensitivity for diagnosing moderate to severe/severe HLAP were 0. 73,0. 45,0. 47,0. 82,0. 65,0. 65 and 0. 88,respectively,the specificity were0. 85,0. 87,0. 90,0. 81,0. 83,0. 83 and 0. 85,respectively,AUC were 0. 84,0. 65,0. 67,0. 87,0. 77,0. 75 and0. 94,respectively. Conclusions: PLR,NLR,MLR,RPR,CLR and CRP can evaluate the severity of HLAP,and the combined PLR,NLR,MLR,RPR an
作者
邹益
李泽宇
王红
ZOU Yi;LI Zeyu;WANG Hong(Department of Gastroenterology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052)
出处
《胃肠病学》
北大核心
2021年第4期218-222,共5页
Chinese Journal of Gastroenterology
基金
2018年度河南省医学科技攻关计划(SBGJ2018036)。
