摘要
多囊卵巢综合征(PCOS)是一种临床高度异质、病因复杂的疾病。近年研究发现,PCOS存在慢性炎症的病理生理过程,而且慢性炎症在PCOS远期并发症的发生发展中起重要作用。主要的慢性炎症因子,如C反应蛋白(CRP)、白细胞介素类(IL)、血浆纤溶酶原激活物抑制物1(PAI-1)、单核细胞趋化因子1(MCF-1)、肿瘤坏死因子(TNF)等在PCOS患者中有不同程度的升高,并且与PCOS患者的胰岛素抵抗、心血管疾病发病风险增高密切相关。
PCOS is a heterogeneous and complicated disease.Recently,it has been demonstrated that chronic inflammation participates in the pathphysiological progress of PCOS,which is closely related with the initiation and progression of long-term complications of PCOS.The elevated levels of main chronic inflammatory cytokines,including C-reactive protein（CRP）,Interleukins（IL）,Plasminogen Activator Inhibitor-1（PAI-1）,Monocyte Chemotactic Factor-1（MCF-1） and Tumor Necrosis Factor（TNF）,are associated with insulin resistance and cardiovascular diseases in women with PCOS.
出处
《国际妇产科学杂志》
CAS
2010年第6期380-382,393,共4页
Journal of International Obstetrics and Gynecology
关键词
多囊卵巢综合征
炎症
胰岛素抗药性
心血管疾病
C反应蛋白质
Polycystic ovarian syndrome
Inflammation
Insulin resistance
Cardiovascular diseases
C-reactive protein
