摘要
目的观察拉贝洛尔联合硝苯地平治疗妊娠期高血压的效果及对相关临床指标和母婴结局的影响。方法回顾性分析2018年4月—2021年3月成都双楠医院妇产科收治的妊娠期高血压患者126例临床资料,根据用药方案不同分为观察组和对照组,每组63例。在常规治疗基础上,对照组予硝苯地平缓释片(Ⅰ)治疗,观察组在对照组基础上加用盐酸拉贝洛尔片治疗,2组患者均连续治疗2周。比较2组炎性因子[白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)]、血管内皮功能指标[内皮缩血管肽-1(ET-1)及一氧化氮(NO)]、血压[收缩压(SBP)、舒张压(DBP)]、凝血功能指标[纤维蛋白原(FIB)、凝血酶时间(TT)、凝血酶原时间(PT)和活化部分凝血活酶时间(APTT)]、分娩方式,以及不良母婴结局(胎儿窘迫、早产、新生儿窒息、产后出血、产后感染等)和不良反应。结果治疗2周后,2组IL-6、TNF-α、hs-CRP、Hcy、ET-1、FIB水平及SBP、DBP均较治疗前降低,NO水平较治疗前上升,TT、PT及APTT则较治疗前延长,且观察组降低、升高或延长幅度大于对照组(P均<0.01);观察组患者顺产率为69.84%,高于对照组的50.79%(χ^(2)=4.775,P=0.029);观察组胎儿窘迫、早产、新生儿窒息、产后出血及产后感染等不良结局的发生率均低于对照组(P<0.05);2组患者均未有严重不良反应发生。结论拉贝洛尔联合硝苯地平治疗妊娠期高血压对患者相关临床指标及母婴结局具有积极影响,可有效控制患者血压及炎性反应状态、改善凝血功能与母婴结局,值得临床推广应用。
Objective To observe the effect of labetalol combined with nifedipine in the treatment of gestational hypertension and its effect on relevant clinical indexes and maternal and infant outcomes.Methods The clinical data of 126patients with gestational hypertension treated in the Department of Obstetrics and Gynecology of Chengdu Shuangnan Hospital from April 2018 to March 2021 were analyzed retrospectively.According to different medication schemes,they were divided into observation group and control group,with 63 cases in each group.On the basis of routine treatment,the control group was treated with nifedipine sustained-release tablets(I),and the observation group was treated with labetalol hydrochloride tablets on the basis of the control group.The patients in both groups were treated for 2 weeks.The inflammatory factors(IL-6,TNF-α,hs-CRP,Hcy),vascular endothelial function indexes(ET-1 and NO),blood pressure(SBP,DBP),coagulation function indexes(FIB,TT,PT and APTT)and mode of delivery were compared between the two groups before and after treatment.And compare the adverse maternal and infant outcomes(fetal distress,premature delivery,neonatal asphyxia,postpartum hemorrhage,postpartum infection,etc.)and the incidence of adverse reactions.Results After 2 weeks of treatment,the levels of IL-6,TNF-α,hs-CRP,Hcy,ET-1,FIB,SBP and DBP in the two groups were lower than those before treatment,the level of NO was higher than that before treatment,while TT,PT and APTT were longer than those before treatment,and the decrease,increase or extension range of the observation group was greater than that of the control group(P<0.01).The rate of spontaneous labor in the observation group was 69.84%,higher than 50.79%in the control group(χ^(2)=4.775,P=0.029).The incidence of adverse outcomes such as fetal distress,premature delivery,neonatal asphyxia,postpartum hemorrhage and postpartum infection in the observation group were lower than those in the control group(P<0.05).There were no serious adverse reactions in both groups.Conclu
作者
廖艺
李小庆
宋启庆
LIAO Yi;LI Xiaoqing;SONG Qiqing(Department of Obstetrics and Gynecology,Chengdu Shuangnan Hospital,Sichuan Province,Chengdu 610000,China)
出处
《临床合理用药杂志》
2022年第14期29-32,36,共5页
Chinese Journal of Clinical Rational Drug Use
关键词
妊娠期高血压
拉贝洛尔
硝苯地平
炎性因子
血管内皮功能
血压
母婴结局
Pregnancy induced hypertension
Labetalol
Nifedipine
Inflammatory factors
Vascular endothelial function
Blood pressure
Maternal and infant outcome
