摘要
感染性角膜炎是世界范围内的眼科常见疾病,是导致视力丧失和失明的重要原因。对微生物性角膜炎发病机制的全面认识、建立相关疾病的动物模型在研究宿主感染的免疫应答和感染机制、药物研发等方面扮演着重要作用,为临床治疗策略选择及基础研究提供了科学依据。随着医学研究的深入,我们对感染性角膜炎动物模型及致病机制进行归纳总结,期望对此有一个全面了解。
Microbial keratitis is a common ocular disease worldwide and is an important cause of vision loss and blindness.A comprehensive understanding of the pathogenesis of microbial keratitis is required for the establishment of animal models of related diseases.These models play an important role in studying the immune response and infection mechanism of host infections and drug development,and provide a scientific evidence for the selection of clinical treatment strategies and pursuing basic research。Here we summarize the animal models and the pathogenic mechanism of infectious keratitis to provide comprehensive understanding of the current research on these models.
作者
陈柳
邱敏
代解杰
CHEN Liu;QIU Min;DAI Jiejie(Chinese Academy of Medical Sciences/Peking Union Medical College Institute of Medical Biology,Kunming 650118;China.2.Kunming Medical University,Kunming 650500)
出处
《中国比较医学杂志》
CAS
北大核心
2022年第4期137-144,共8页
Chinese Journal of Comparative Medicine
基金
NSFC-云南联合基金重点支持项目(U1702282)
云南省科技人才和平台计划项目(2017HC019)
昆明市科技创新团队(2019-1-R-2483)。
