摘要
目的探究肝衰竭患者乙型肝炎病毒(HBV)-脱氧核糖核酸(DNA)载量与炎性因子及肝纤维化指标的相关性。方法选取2018年11月至2020年11月就诊于平顶山市第一人民医院120例肝衰竭患者,根据HBV-DNA载量分为阴性组(HBV-DNA载量<10^(3) copies/mL)26例、低载量组(10^(3) copies/mL≤HBV-DNA载量<10^(5) copies/mL)46例、中载量组(10^(5) copies/mL≤HBV-DNA载量≤10^(7) copies/mL)29例和高载量组(HBV-DNA载量>10^(7) copies/mL)19例,检测并比较各组血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)水平;血清Ⅳ型胶原(CⅣ)、透明质酸(HA)、层黏连蛋白(LN)、Ⅲ型前胶原(PCⅢ)水平;Pearson相关系数分析肝衰竭患者HBV-DNA载量与炎性因子及肝纤维化指标的相关性。结果随着血清HBV-DNA载量的升高,血清TNF-α、IL-6、hs-CRP水平逐渐升高(P<0.05);随着血清HBV-DNA载量的升高,血清CⅣ、HA、LN、PCⅢ水平升高(P<0.05);肝衰竭患者HBV-DNA载量与TNF-α、IL-6、hs-CRP、CⅣ、HA、LN、PCⅢ呈正相关。结论肝衰竭患者HBV-DNA载量与炎性因子及肝纤维化指标具有密切的相关性,对临床诊治肝衰竭意义重大。
【Objective】To investigate the relationship between HBV DNA load and inflammatory factors and liver fibrosis in patients with liver failure.【Methods】A total of 120 patients with liver failure in our hospital from November 2018 to November 2020 were selected and divided into negative group(HBV-DNA load<10^(3) copies/mL)(n=26),low load group(10^(3) copies/mL≤HBV-DNA load<10^(5) copies/mL)(n=46),medium load group(10^(5) copies/mL≤HBV-DNA load≤10^(7) copies/mL)(n=29)and high load group(HBV-DNA load>10^(7) copies/mL)(n=19)according to HBV-DNA load,the serum levels of TNF-α,IL-6,hs-CRP,CⅣ,HA,LN and PCⅢwere detected and compared.Pearson correlation coefficient was used to analyze the correlation between HBV-DNA load,inflammatory factors and liver fibrosis indexes.【Results】With the increase of serum HBV-DNA load,serum TNF-α,IL-6,hs-CRP levels increased gradually,and the difference was statistically significant(P<0.05).With the increase of serum HBV-DNA load,serum CⅣ,HA,LN,PCⅢlevels were significantly increased,and the difference was statistically significant(P<0.05).There was a positive correlation between HBV-DNA load and TNF-α(r=0.223,0.255,0.439,0.316,P<0.05),IL-6(r=0.363,0.394,0.438,0.504),hs-CRP(r=0.696,0.787,0.559,0.244,P<0.05),CⅣ(r=0.396,0.365,0.318,0.441,P<0.05),HA(r=0.438,0.599,0.590,0.439,P<0.05),LN(r=0.601,0.514,0.700,0.508,P<0.05),PCⅢ(r=0.229,0.263,0.344,0.371,P<0.05)in patients with liver failure.【Conclusion】HBV-DNA load is closely related to inflammatory factors and liver fibrosis indexes in patients with liver failure,which is of great significance for clinical diagnosis and treatment of liver failure.
作者
庞康清
马洪德
杨汝磊
庞国宏
PANG Kangqing;MA Hongde;YANG Rulei;PANG Guohong(Department of Infectious Diseases,Pingdingshan First People's Hospital,Pingdingshan,Henan 467000,China)
出处
《中国医学工程》
2022年第5期21-25,共5页
China Medical Engineering
