摘要
目的研究母乳喂养对乙型肝炎病毒(HBV)携带妇女垂直传播的影响。方法选取2018年4月至2020年12月于温州医科大学附属台州妇女儿童医院生产的105例HBV携带产妇为研究对象,根据新生儿喂养方式的不同分为观察组(母乳喂养)48例和对照组(配方奶粉喂养)57例,测定产妇妊娠期HBV-DNA载量,并分为高HBV-DNA载量(>1×10^(6) IU/mL)和低HBV-DNA载量(≤1×10^(6) IU/mL)亚组,比较产妇及婴儿HBV感染情况。结果观察组新生儿出生时及出生6个月后HBV血清学指标HBsAg、HBeAg及HBV-DNA>100IU/mL的阳性率与对照组新生儿比较差异均无统计学意义(均P>0.05);血清HBV-DNA高载量产妇的初乳HBV-DNA阳性率在观察组及对照组中均高于低载量产妇,差异有统计学意义(χ^(2)值分别为6.352、5.398,均P<0.05),但两组初乳HBV-DNA阳性率在不同血清HBV-DNA载量产妇中表达情况差异均无统计学意义(均P>0.05);观察组新生儿出生6个月后母婴垂直传播阻断成功率和对照组比较差异不具有统计学意义,且不同血清HBV-DNA载量产妇的母婴垂直传播阻断率比较差异不具有统计学意义(均P>0.05)。结论在接受主-被动联合免疫治疗后,HBV携带妇女新生儿发生HBV感染的概率不会因为母乳喂养而增加。
Objective To study the effect of breastfeeding on the vertical transmission of hepatitis B virus-carrying women.Methods 105 HBV-carrying women who were born in Taizhou Women and Children’s Hospital of Wenzhou Medical University from April 2018 to December 2020 were selected as research objects and were divided into observation groups(breastfeeding) with 48 cases and the control group(formula fed) with 57 cases according to the different feeding methods of newborns.The HBV-DNA load during pregnancy was measured and divided into high HBV-DNA load(>1×10^(6) IU/mL) and low HBV-DNA load(≤1×10^(6) IU/mL) subgroups, to compare the HBV infection status of mothers and infants.Results There were no significant differences in the positive rates of HBsAg, HBeAg and HBV-DNA>100 IU/mL at birth and 6 months after birth between the observation group and the control group(all P>0.05).The positive rates of colostrum HBV-DNA in women with high serum HBV-DNA load in the observation group and control group were higher than in low load women, the differences were statistically significant(χ^(2)=6.352 and 5.398,respectively, both P<0.05).But the two groups of colostrum HBV-DNA positive rate in different serum HBV-DNA load maternal expression differences had no statistical significance(P>0.05).There was no statistically significant difference in the success rate of blocking mother-to-child vertical transmission between the observation group and the control group after 6 months of birth, and there was no statistically significant difference in the rate of blocking mother-to-child vertical transmission between the women with different serum HBV-DNA load(all P>0.05).Conclusion After receiving active-passive combined immunotherapy, the probability of HBV infection in newborns of HBV-carrying women will not increase due to breastfeeding.
作者
周瑶瑶
陈凤云
罗培英
ZHOU Yaoyao;CHEN Fengyun;LUO Peiying(Department of Gynaecology and Obstetrics,Taizhou Women and Children’s Hospital of Wenzhou Medical University,Zhejiang Taizhou 318000,China)
出处
《中国妇幼健康研究》
2021年第5期682-686,共5页
Chinese Journal of Woman and Child Health Research
关键词
母乳喂养
乙型肝炎病毒
垂直传播
婴儿
breastfeeding
hepatitis B virus
vertical transmission
infant
