摘要
目的:观察清肺颗粒对慢性阻塞性肺疾病急性加重痰热郁肺证患者的血清炎症因子(IL-6、IL-8、TNF-α)以及外周血单核细胞Toll受体(TLR2、TLR4)表达等的影响。方法:将符合AECOPD(痰热郁肺证)的120例患者分为两组,每组各60例。治疗组60例予基础西医加服清肺颗粒治疗,对照组60例予基础西医加服清肺颗粒模拟剂治疗,两组治疗时间均为10d。观察两组治疗前后的中医证侯疗效、中医主症积分、血清炎症因子(IL-6、IL-8、TNF-α)水平、外周血单核细胞Toll样受体(TLR-2、TLR-4)表达水平的差异。结果:最终共有108例患者完成研究,其中治疗组55例、对照组53例。治疗组的中医证侯疗效为90.91%,显著高于对照组的疗效(73.58%),P<0.05;两组患者治疗后咳、痰、喘症状均较治疗前改善(P<0.05),且治疗组在咳、痰、喘三项主症的改善程度方面优于对照组(P<0.05);两组患者治疗后血清IL-6、IL-8、TNF-α水平均下降(P<0.05),治疗组血清IL-6、IL-8、TNF-α水平的下调明显优于对照组(P<0.05);两组患者治疗后TLR2、TLR4水平均较治疗前上升(P<0.05),且治疗组上升更明显(P<0.05)。结论:血清炎症因子与外周血单核细胞TOLL样受体表达具有负相关性,表明清肺颗粒在减轻气道炎症反应的同时又可增强机体免疫功能;两组患者至治疗结束后心电图、肝肾功能、尿常规均未见明显异常变化,说明清肺颗粒能较好地减轻患者咳、痰、喘症状,在降低气道炎症反应的同时有效调节机体固有免疫,且临床应用安全。
Objective:To observe the effect of Qingfei Particles in treating AECOPD patients belonging to the type of Phlegm-Heat obstructing lung to impact inflammatory factors(IL-6,IL-8,TNF-α)in serum and Toll-like receptors(TLR-2,TLR-4)in peripheral blood mononuclear cells.Methods:120patients included in the standard of the AECOPD patients belonging to the type of Phlegm-Heat obstructing lung were randomly divided into two gruops,In the treatment group(n=60)were treated with the combined basic western medicine with Qingfei Particles,and the control group(n=60)was treated with the combined basic western medicine with the Qingfei Particles placebo,and the two groups were treated for 10days.To observe th TCM syndrome effect;the primary symptom scores;serum(IL-6,IL-8,TNF-α);Toll-like receptors(TLR-2,TLR-4)of the two groups before and after the treatment.Results:108patients(treatment group=55,control group=53)completed the clinical research.The TCM syndrome effect of treatment group was 90.91%higher than that of control group 73.58%(P<0.05).the primary symptoms(cough,expectorine,wheezing)were improved significantly(P<0.05),the improvement of cough,expectorine,Wheezing in the treatment group was better than that in the control group(P<0.05).The serum levels of IL-6,IL-8and TNF-αAfter treatment was significantly decreased in two groups(P<0.05),and the treatment group were significantly lower than those in the control group(P<0.05).TLR2and TLR4level in both groups were higher than before treatment(P<0.05),and the treatment group reduced more significantly(P<0.05).Conclusion:Inflammatory factors(IL-6,IL-8,TNF-α)in serum were good at that expression level of Toll-like receptors(TLR-2,TLR-4)in peripheral blood mononuclear cells.indicating that Qingfei Particles reduce airway inflammatory response while enhancing immunity.No significant abnormal changes in electrocardiogram,liver and kidney function and urine routine were observed in the two groups.It’s to prove Qingfei Particles can better improve the symptoms of cough,sputum
作者
刘佳玉
折哲
石克华
Liu Jiayu;Zhe Zhe;Shi Kehua(Pulmonary Disease Department,Shanghai Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200071,China)
出处
《亚太传统医药》
2022年第5期78-83,共6页
Asia-Pacific Traditional Medicine
基金
上海市科委项目(17401970900)。
关键词
慢性阻塞性肺疾病
急性加重
清肺颗粒
炎症因子
TOLL样受体
Chronic Obstructive Pulmonary Disease
Acute Exacerbation
Qingfei Particles
Inflammatory Factor
Toll-Like Receptor
