摘要
中性粒细胞的呼吸爆发功能在宿主防御及炎症反应中起着重要的作用。该反应起始于吞噬小体表面的NADPH氧化酶的活化 ,它将O2 还原成O-2 ,随后O-2 经歧化作用转变成H2 O2 。在有Cl-的情况下 ,髓过氧化物酶可以催化H2 O2 生成HOCl。HOCl是高效的杀菌剂 ,通过与邻近的巯基、氨基反应发挥其杀伤毒性。呼吸爆发在清除微生物的同时也会对机体正常组织造成损伤 。
Neutrophils respiratory burst plays an important role in the inflammatory response and host defence against invading pathogens. It is initiated by the activation of NADPH oxidase in the phagolysosome membrane. Activated NADPH reduces O 2 to O - 2 and is followed by dismutation to hydrogen peroxide. In the presence of Cl -,the myeloperoxidase catalyzes H 2O 2 to yield HOCl, an effective antimicrobial agent which reacts with neighboring thiol and amino residues to execute its toxicity. However, respiratory burst can also cause tissue damage and the metabolisms of reactive oxygen may be the pathogenesis of many diseases.
出处
《基础医学与临床》
CSCD
北大核心
2004年第1期1-6,共6页
Basic and Clinical Medicine
基金
国家自然科学基金 ( 3 0 170 878)
