摘要
目的探讨卵泡期超长方案对不同年龄段患者的临床疗效。方法回顾性分析2017年6月至2019年6月采用卵泡期超长方案患者共622例。根据不同年龄段分为A组(25~30岁,269例)、B组(31~34岁,182例)和C组(35~42岁,171例)。比较三组患者的基线资料、促排卵结局、胚胎移植及妊娠情况。结果HCG日雌二醇水平A组明显高于B组和C组,差异有统计学意义(P<0.05)。促性腺激素使用总量随年龄升高呈上升趋势,A组明显低于B组和C组,差异有统计学意义(P<0.05)。获卵数随着年龄升高而减少,C组明显低于A组和B组,差异有统计学意义(P<0.05)。D3优胚率,B组低于A组和C组,差异有统计学意义(P<0.05)。A组种植率最高达52.87%,明显高于B组和C组,差异有统计学意义(P<0.05)。A组的临床妊娠率及持续妊娠率均明显高于B组、C组,差异均有统计学意义(P<0.05)。三组的流产率比较,差异无统计学意义(P>0.05)。三组均未发生早发LH峰和重度卵巢过度刺激综合征。结论卵泡期超长方案在不同年龄段患者中都获得理想的优胚率及临床妊娠率,对早期流产率并未产生不利影响。
Objective To explore the prolonged protocol on patients of different ages.Methods From June 2017 to June 2019,a total of 622 patients were analyzed retrospectively.According to different age stages,they were divided into Group A(269 cases aged 25~30 years),Group B(182 cases aged 31~34 years)and Group C(171 cases aged 35~42 years).The baseline data,ovulation induction outcome,embryo transfer and pregnancy were compared among the three groups.Results The level of estradiol in Group A was significantly higher than that in Group B and Group C on HCG day with statistical significance(P<0.05).The total amount of gonadotropin used increased with age,and that in Group A was significantly lower than that in Group B and C with statistical significance(P<0.05).The number of eggs obtained decreased with age,and that in Group C was significantly lower than that in Group A and Group B with statistical significance(P<0.05).The rate of excellent embryos in Group B was lower than that in Group A and C,and the difference was statistically significant(P<0.05).The highest implant rate in Group A was 52.87%,which was significantly higher than that in Group B and Group C with statistical significance(P<0.05).The clinical pregnancy rate and persistent pregnancy rate in Group A were significantly higher than those in Group B and Group C with statistical significance(P<0.05).There was no significant difference in abortion rate among the three groups(P>0.05).No early LH peak and severe ovarian hyperstimulation syndrome occurred in the three groups.Conclusion Prolonged protocol has achieved ideal excellent embryo rate and clinical pregnancy rate in patients of different ages,and has no adverse effect on early abortion rate.
出处
《浙江临床医学》
2022年第4期513-515,共3页
Zhejiang Clinical Medical Journal
基金
温州市科技计划项目(Y20180021)。
关键词
卵泡期超长方案
体外受精-胚胎移植
促性腺激素
妊娠结局
Prolonged protocol
In vitro fertilization/intracytoplasmic sperm injection-embryo transfer
Gonadotropin
Pregnancy outcome
