摘要
目的探讨GnRH括抗剂和GnRH激动剂短方案对卵巢功能低下患者行体外受精超促排卵治疗的临床结局的比较。方法回顾性分析2015年1月2016年5月在本中心采用GnRH-ant方案和GnRH-a短方案促排卵行IVF-ET治疗患者120例的临床资料,随机分成A组与B组,均为60个周期,比较两组的Gn用量,HCG日相关激素水平,获卵率、受精率、优胚率等实验室结果及临床妊娠率。结果 A组的Gn总用量,HCG日雌二醇（E2）水平,获卵率,优胚率,妊娠率显著高于B组,差异有统计学意义（P〈0.05）。HCG日LH和P值的水平,A组明显低于B组,差异有统计学意义（P〈0.05）,而两者在受精率及卵裂率,差异无统计学意义（P〉0.05）。结论对卵巢功能低下患者,GnRH拮抗剂方案较常规激动剂短方案能提高获卵率、优胚率和临床妊娠率,无疑是一种较可靠的用药方案。
Objective Objective to investigate the clinical outcomes of GnRH antagonist and GnRH agonist short protocol in the treatment of patients with ovarian insufficiency in vitro fertilization and superovulation.Methods A retrospective analysis from January 2015 to May 2016 in the center by using GnRH-ant scheme and GnRH-a scheme for short ovulation and clinical data of 120 cases of IVF-ET treated patients,were randomly divided into A group and B group were 60 cycles,compared with two groups of Gn dosage,HCG,hormone levels,oocyte rate,fertilization rate,embryo the rate of pregnancy rate and clinical laboratory results.ResuIts The total amount of Gn,HCG estradiol（E2） level,egg rate,embryo rate and pregnancy rate of A group were significantly higher than those of B group,the difference was statistically significant（P〈0.05）.HCG,LH and P level of A group was significantly lower than B group,the difference was statistically significant（P〈0.05）,and both the fertilization rate and cleavage rate,the difference was not statistically significant（P〉0.05）.Conclusion For the patients with low ovarian function,the GnRH antagonist regimen can improve the rate of oocyte capture,embryo rate and pregnancy rate compared with the routine agonist,which is undoubtedly a reliable drug regimen.
出处
《实用妇科内分泌电子杂志》
2016年第20期60-61,共2页
Electronic Journal of Practical Gynecological Endocrinology
