摘要
目的 分析脑肿瘤切除术患儿术中回收自体血中循环肿瘤细胞(CTC)含量及回收式自体输血对预后的影响,评估回收式自体输血联合白细胞滤器在小儿脑肿瘤术中应用的安全性。方法 检测术中回收自体血的脑肿瘤患儿手术前后颈内静脉、储血罐内、白细胞滤器滤过后血液中CTC的含量。并比较自体输血和异体输血组患儿术中出血量、输血量的情况和预后指标。结果 与术前颈内静脉血液比较,储血罐内、白细胞滤器滤过后及术后颈内静脉血液中CTC的含量差异无统计学意义(P> 0.05)。与异体输血组比较,自体输血组手术及麻醉时间较长,术中出血量较多(P <0.05),但两组术中异体红细胞、血浆和冷沉淀输注量差异无统计学意义(P> 0.05);两组患儿在术后并发症发生率、术后机械通气持续时间、术后住院时间和术后复发率方面比较差异无统计学意义(P> 0.05)。结论 通过回收技术及白细胞滤器处理的自体血中CTC数量不会增加,在小儿脑肿瘤切除术中应用自体血回收联合白细胞滤器技术对术后肿瘤复发率及预后影响不明显。
Objective To analyze the content of circulating tumor cells(CTCs)in autologous blood recovered during brain tumor resection and the effect of autologous blood transfusion on prognosis,to evaluate the safety of autologous blood recovery combined with leukocyte filter in brain tumor resection in children.Methods The content of CTCs in children undergoing brain tumor resection before and after autologous blood transfusion was analyzed,and the effect of leukocyte filter on removing circulating tumor cells was evaluated.The intraoperative blood loss,blood transfusion and prognosis of children in autologous blood transfusion group and allogeneic blood transfusion group were compared.The effect of autologous blood transfusion on postoperative recovery was analyzed.Results There was no significant difference in the content of CTCs in autologous blood transfusion group before and after the operation(P > 0.05).The operation and anesthesia time of the autologous blood transfusion group were longer and the amount of intraoperative bleeding was more when compared with the allogeneic blood transfusion group(P < 0.05),but there was no significant difference in the amount of allogeneic red blood cell,plasma and cold precipitation between the two groups(P > 0.05).There was no significant difference between the two groups in terms of postoperative complications,duration of postoperative mechanical ventilation,postoperative hospital stay and postoperative recurrence rate(P > 0.05).Conclusion The application of autologous blood recovery combined with leukocyte filter in pediatric brain tumor resection has no effect on postoperative tumor recurrence and prognosis,and it can be safely applied in clinical practice.
作者
张娜
魏伟
许新科
陈程
谢观土
徐颖怡
ZHANG Na;WEI Wei;XU Xinke;CHEN Cheng;XIE Guantu;XU Yingyi(Department of Anaesthesia and Perioperative Medicine,Guangzhou 510623,China;不详)
出处
《实用医学杂志》
CAS
北大核心
2022年第7期873-878,共6页
The Journal of Practical Medicine
基金
广州市卫生健康科技项目(编号:20191A011034)。
关键词
小儿
肿瘤
自体血回收
白细胞滤器
预后
children
tumor
autologous blood salvage
leukocyte filter
prognosis
