摘要
高原低压低氧环境中,机体会发生一系列应激反应,可造成脑、心、肺和胃肠等重要脏器的缺氧损伤。机体的氧化应激损伤、免疫系统受损以及细胞能量代谢障碍是高原缺氧损伤的主要机制。中药具有多成分、多靶点且资源丰富等特点,在防治高原缺氧方面具有悠久的药用历史和广阔的开发前景。本文全面总结了对高原缺氧和高原反应具有保护作用的中药品种及其复方制剂,并对常用中药的主要药效成分、药效途径和作用机制等方面的研究现状进行了综述,以期为防治高原缺氧新的中成药、保健食品和普通食品的开发及应用提供参考。
Organisms can suffer from a series of stress reactions in response to low pressure and low oxygen in highaltitude environment,which can cause hypoxia damage to many vital organs such as brain,heart,lung and gastrointestinal tract.Oxidative stress,immune system damage and cell energy metabolism disorders are the main mechanisms of high-altitude hypoxia injury.traditional Chinese medicine is characterized by multi-component,multitarget and abundant resources,which has a long history of medicinal and broad development prospects in preventing and treating high-altitude hypoxia.This paper comprehensively summarized the types of traditional Chinese medicines and Chinese herbal formula that have protective effects on high-altitude hypoxia,and reviews the current research advances on the major species of traditional Chinese medicines in terms of their main active components,pharmacodynamic pathways and action mechanisms.We hope to provide reference for the development and application of Chinese traditional patent medicines,health products and foods for prevention and treatment of high-altitude hypoxia.
作者
李雪
李学芳
浦雪梅
陈晓娇
贺森
李静平
顾雯
杨兴鑫
张范
俞捷
Li Xue;Li Xuefang;Pu Xuemei;Chen Xiaojiao;He Sen;Li Jingping;Gu Wen;Yang Xingxin;Zhang Fan;Yu Jie(School of Chinese Materia Medica,Yunnan Key Laboratory of Southern Medicinal Resource,Yunnan University of Chinese Medicine,Kunming 650500,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2021年第12期4669-4677,共9页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金委员会地区科学基金项目(81960710):基于谱效先导整合药理学的滇黄精质量标志物研究,负责人:俞捷
云南省科学技术厅基础研究计划-杰出青年项目(202001AV070007):经典古方黄精丸干预糖脂代谢的药效及作用机制研究,负责人:俞捷
云南省科学技术厅基础研究专项-面上项目(202101AT070272)“:云药”滇黄精抗高原缺氧功效和分子机制研究,负责人:张范。
关键词
高原缺氧
中药
药效成分
作用机制
High-altitude hypoxia
Traditional Chinese medicine
Main active components
Action mechanisms
