摘要
高原环境具有低压性低氧、寒冷、辐射强等一系列特点,其中低氧对机体的影响最大。急性高原病是指人在到达海拔超过2500米的高原时,可能发生的急性高原反应、高原脑水肿以及高原肺水肿的总称。随着人们对进入高原地区的需求日益增加,急性高原病的发病机制、预防和治疗也得到了更多的关注。目前,该病的发病机制尚未完全阐明,防治也并未出现更多的进展。本文总结了急性高原病发病的可能机制,旨在为急性高原病的预防和治疗提供新的作用靶点。
High altitude environment is characterized by hypobaric hypoxia, low temperature and intense solar radiation.Among them,the most prominent one is hypoxia,and it can influence healthy individuals in many aspects.Acute high-altitude illness refers to acute mountain sickness（AMS）,high-altitude cerebral edema（HACE）and high-altitude pulmonary edema（HAPE）which people may suffer from when ascending to an altitude level of over 2500 m.With more and more people having the demand into the plateau areas,the pathogenesis,prevention and treatment of acute high-altitude illness have received more attention.In present,the pathogenesis of the disease remains unclear,and thus little progress has been made in its pharmacologic prevention and treatment.In this article,we summarized the possible mechanisms of the illness in order to provide new targets for its prevention and treatment.
出处
《中华老年多器官疾病杂志》
2017年第11期859-862,共4页
Chinese Journal of Multiple Organ Diseases in the Elderly
基金
国家科技重大专项重大新药创制(2014ZX09J14102-02A)~~
关键词
高原病
低氧
机制
altitude sickness
hypoxia
mechanism
