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mTOR信号通路在急性肺损伤中调控作用的研究进展 被引量:3

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摘要 急性肺损伤(acute lung injury,ALI)是一种毁灭性的呼吸系统疾病,导致内皮细胞障碍和细胞骨架改变,从而进展为肺水肿、呼吸衰竭及多器官功能障碍综合征(multiple organ dysfunction syndrome,MODS),最终导致死亡的发生[1]。虽然近些年对于肺损伤的研究和治疗取得了巨大的进展,但是死亡率仍然较高[2],幸存者可能存在严重的肺纤维化,而导致低氧血症和呼吸窘迫[3],对患者造成重大的心理和生理损伤[4–6],给患者家庭和社会造成重大的医疗负担。
出处 《临床肺科杂志》 2022年第6期919-924,共6页 Journal of Clinical Pulmonary Medicine
基金 国家自然基金资助项目(No.81673791) 安徽省重点研究与开发计划项目(NO.1804h08020287)。
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  • 3Carracedo A,Ma L,Teruya-Feldstein J,Rojo F,Salmena L,Alimonti A,et al.Inhibition of mTORC1 leads to MAPK pathway activation through a Pl3K-dependent feedback loop in human cancer.J Clin Invest 2008; 118:3065-3074. 被引量:1
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