摘要
细胞焦亡是近年来新发现的一种有别于细胞坏死、凋亡、自噬的细胞程序性死亡的新形式。酒精性肝病(ALD)是长期饮酒过量导致慢性酒精中毒的主要表现之一。目前研究证实细胞焦亡涉及ALD的发病机制为酒精诱导的肝细胞炎症小体通路激活促进肝细胞的焦亡。此机制与中医“痰瘀毒”导致ALD的发病机制有其相似之处。因此,从“痰瘀毒”病机探讨细胞焦亡在ALD中的发病分子机制,有望为ALD的治疗提供新的临床指导原则。
Pyroptosis is a new form of programmed cell death, which is different from cell necrosis, apoptosis and autophagy. Alcoholic liver disease(ALD) is one of the main manifestations of chronic alcoholism caused by long-term excessive drinking. Current studies have confirmed that the pathogenesis of ALD involved in pyroptosis is that alcohol-induced activation of hepatocyte inflammosome pathway promoting pyroptosis of hepatocytes. This mechanism is similar to the pathogenesis of ALD caused by phlegm-stasis-toxin in TCM. Therefore, it is expected to provide a new clinical guiding principle for the treatment of ALD and to explore the molecular mechanism of cell pyroptosis in ALD from the pathogenesis of phlegm-stasis-toxin.
作者
周艳彩
孔晨帆
杨佳潞
朱晓东
金承烨
孙劲晖
ZHOU Yancai;KONG Chenfan;YANG Jialu;ZHU Xiaodong;JIN Chengye;SUN Jinhui(Beijing University of Chinese Medicine,Beijing 100029,China;Shanghai University of Traditional Chinese Medicine,Shanghai 201201,China;Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China)
出处
《中医药学报》
CAS
2022年第5期1-4,共4页
Acta Chinese Medicine and Pharmacology
基金
国家自然科学基金项目(81573969)
北京中医药大学东直门医院2020年度科技创新专项(DZMKJCX-2020-016)。
关键词
细胞焦亡
酒精性肝病
痰瘀毒
Pyroptosis
Alcoholic liver disease
Phlegm-stasis-toxin
