摘要
骨缺损修复一直是再生医学研究领域中的热点和难题。近年来骨组织工程技术的飞速发展极大提升了骨缺损修复水平, 但是骨再生研究仍然面临诸多挑战, 如病理条件下骨再生困难、再生调控机制不清等, 导致骨组织工程技术发展遇到瓶颈, 制约了对骨再生修复的深入研究。骨类器官是一个全新概念, 是一类特殊复杂的硬组织, 可根据生物学基础理论, 借助组织工程3D培养技术在体外构建, 模拟体内骨组织的复杂生物学功能。骨类器官有助于阐明骨再生调控机制、筛选组织工程材料、促进骨再生修复, 在骨再生研究中展现出广阔的应用前景。笔者就骨类器官的特点、构建策略及价值进行初步探讨, 为骨缺损治疗提供新思路。
Bone tissue repair has long been a hot topic and difficult issue in the field of regenerative medicine research.Although the rapid development of bone tissue engineering technology significantly accelerates the level of bone repair in recent years,bone regeneration research still faces many challenges such as difficulty in regeneration under pathological condition and unclear regenerative regulatory mechanisms.As a result,the evelopment of bone tissue engineering technology encounters a bottleneck,restricting more researches over bone regeneration and repair.As a novel concept,bone organoids are proposed and constructed in vitro with the help of tissue engineering technology based on biological theory,and can simulate the complex biological functions of bone in vivo.Bone organoids show broad application prospects in the research of bone regeneration,including elucidating regulatory regeneration mechanisms,screening biomaterials and promoting regeneration,etc.In this study,the authors preliminarily discuss the features,construction and value of bone organoids so as to provide new insight for the treatment of bone defect.
作者
陈晓
苏佳灿
Xiao Chen;Jiacan Su(Department of Orthopedic Trauma,First Affiliated Hosptial,Naval Medical University,Shanghai 200433,China;Institute of Translational Medicine,Shanghai University,Shanghai 200444,China)
出处
《中华创伤杂志》
CAS
CSCD
北大核心
2022年第4期293-296,共4页
Chinese Journal of Trauma
基金
国家重点研发计划(2018YFC2001500)
国家自然科学基金(82172098, 81871099)
上海市青年科技启明星计划(21QA1412000)。
关键词
骨再生
组织工程
骨类器官
Bone regeneration
Tissue engineering
Bone organoids
