摘要
目的 观察血清同型半胱氨酸(Homocysteine,Hcy)水平与冠心病的严重程度之间的关联及临床意义。方法 研究选取青海省心脑血管病专科医院2018年6月至2021年6月间以医院为基础的新诊断的冠心病患者497例为研究对象,收集患者社会人口学信息、冠心病病情信息,以及确诊时HCY水平信息等。多角度探讨血清HCY水平与冠心病的严重程度之间的关联。数据收集和分析使用SPSS 19.0统计软件包完成。结果所有患者HCY血清平均水平为(20.23±2.18)μmol/L,其中HCY超标330例,HCY未超标167例;不同性别、不同年龄段患者、不同海拔地区及不同类型冠心病患者间血清HCY水平差异有统计学意义(P<0.05);不同性别患者HCY水平与冠心病的严重程度的相关系数为(r_(1)=0.356,r_(2)=0.198,P<0.05);不同年龄段患者HCY水平与与冠心病的严重程度的相关系数为(r_(1)=0.304,r_(2)=0.50,r_(3)=0.217 r4=0.185,P<0.05);不同海拔地区生活的患者HCY水平与与冠心病的严重程度的相关系数为(r_(1)=0.129,r_(2)=0.369,r_(3)=0.473,P<0.05);不同类型冠心病患者HCY水平与冠心病的严重程度的相关系数为(r_(1)=0.137,r_(2)=0.200,r_(3)=0.205,P<0.05);logistic多因素回归分析结果显示血清HCY、海拔高度、性别及年龄是患者发生冠心病的独立危险因素(P<0.05)。结论 不同性别患者中男性患者血清HCY水平与冠心病严重程度关联更强;40~50年龄段患者中HCY水平与冠心病严重程度关联最强;高海拔患者中血清HCY水平与冠心病严重程度关联更强,血清HCY检查可用于冠心病的诊断和评估冠心病冠脉病变程度。
Objective To observe the correlation and clinical significance between serum homocysteine(HCY)level and the severity of coronary heart Disease(CHD).Methods A total of 497 hospital-based patients with newly diagnosed coronary heart Disease from June 2018 to June 2021 in our hospital were selected as the study subjects.The patients′sociodemographic information,coronary heart Disease condition information and HCY level information at diagnosis were collected.The correlation between serum HCY level and the severity of coronary heart disease was analyzed from multiple perspectives.Data were collected and analyzed using SPSS 19.0 statistical software package.Results The average level of HCY in all patients was(20.23±2.18)μmol/L,among which 330 cases exceeded the standard level of HCY and 167 cases did not exceed the standard level.There were statistically significant differences in serum HCY levels among patients with different genders,different ages,different altitudes,and different types of coronary heart Disease(P<0.05).The correlation coefficients between HCY level and the severity of CHD in different genders were r_(1)=0.356,and r_(2)=0.198,P<0.05.The correlation coefficients between HCY level and the severity of CHD in patients of different ages were r_(1)=0.304,r_(2)=0.50,r_(3)=0.217,and r4=0.185,P<0.05.The correlation coefficients between HCY level and the severity of CHD in patients living at different altitudes were r_(1)=0.129,r_(2)=0.369,and r_(3)=0.473,P<0.05.The correlation coefficients between HCY level and the severity of CHD in patients with different types of CHD was r_(1)=0.137,r_(2)=0.200,and r_(3)=0.205,P<0.05.Logistic multivariate regression analysis showed that serum HCY,altitude,gender and age were independent risk factors for coronary heart Disease(P<0.05).Conclusion The correlation between serum HCY level and the severity of CHD is stronger in male patients than in female patients. The correlation between HCY level and the severity of CHD was strongest inpatients aged 40 -50. Serum HCY lev
作者
周茜
白洁
张晶
ZHOU Qian;BAI Jie;ZHANG Jing(Department of Hypertension,Qinghai Cardiovascular and Cerebrovascular Disease Hospital,Xining,Qinghai 810000,China)
出处
《公共卫生与预防医学》
2022年第3期146-149,共4页
Journal of Public Health and Preventive Medicine
基金
2020年度职业危害识别与控制湖北省重点实验室开放(OHIC2020Y04)。
