摘要
目的探讨非高密度脂蛋白胆固醇(non-HDL-C)/高密度脂蛋白胆固醇(HDL-C)比值与早发男性急性ST段抬高型心肌梗死(STEMI)发生的相关性。方法纳入165例早发男性STEMI患者(早发男性组),选取同时间段因胸痛、胸闷就诊行冠状动脉造影排除冠心病的31例年龄≤55岁男性作为对照组,比较两组患者的临床资料。采用多因素二元logistic回归分析评价non-HDL-C/HDL-C比值与早发男性STEMI发生的相关性,采用受试者工作特征(ROC)曲线分析non-HDL-C/HDL-C比值对早发男性STEMI发生的预测价值。结果早发男性组糖尿病患者比例、non-HDL-C水平、non-HDL-C/HDL-C比值、低密度脂蛋白胆固醇(LDL-C)/HDL-C比值均高于对照组,HDL-C水平低于对照组(P<0.05)。多因素二元logistic回归分析结果显示,较高的non-HDL-C/HDL-C比值与早发男性STEMI风险增加相关(OR=2.96,95%CI 1.82~4.83,P<0.001)。ROC曲线分析结果显示,与高血压、糖尿病相比,non-HDL-C/HDL-C对早发男性STEMI发生的诊断价值及预测准确率更高。结论non-HDL-C/HDL-C比值与早发男性STEMI的发生显著相关。
Objective To explore the correlation of non-high density lipoprotein cholesterol(non-HDL-C)to high density lipoprotein cholesterol(HDL-C)ratio with early-onsetacute ST segment elevation myocardial infarction(STEMI)in men.Methods A total of 165 male patients with early-oneset STEMI were selected as early-oneset male group,31 male patients aged≤55 years old who received coronary angiography and were excluded from coronary heart disease due to chest pain and distress during the same period were selected as control group.Clinical data were compared between the two groups.Correlation of non-HDL-C/HDL-C ratio with early-oneset STEMI in men was evaluated by multivariate binary logistic regression analysis.Receiver operating characteristic(ROC)curve was used to analyze the value of non-HDL-C/HDL-C ratio predicting early-onset STEMI in men.Results Proportion of patients with diabetes mellitus,non-HDL-C level,non-HDL-C/HDL-C ratio and low-density lipoprotein cholesterol(LDL-C)/HDL-C ratio inearly-onset male group were higher than those in control group,while HDL-C level was lower than that in control group(P<0.05).Multivariate binary logistic regression analysis showed that higher non-HDL-C/HDL-C ratio was correlated with increased risk of early-onset STEMI in men(OR=2.96,95%CI 1.82~4.83,P<0.001).ROC curve analysis showed that compared with hypertension and diabetes mellitus,non-HDL-C/HDL-C had higher diagnostic value and predictive accuracy for early-onset STEMI in men.Conclusion Non-HDL-C/HDL-C ratio is significantly correlated with the occurrence of early-onset STEMI in men.
作者
欧巧云
陶丽华
温详
张静
杨林飞
孙明裕
高坡
Ou Qiaoyun;Tao Lihua;Wen Xiang;Zhang Jing;Yang Linfei;Sun Mingyu;Gao Po(Department of Cardiology,the Second People’s Hospital of Hefei,Hefei 230011,China;不详)
出处
《临床内科杂志》
CAS
2022年第5期318-322,共5页
Journal of Clinical Internal Medicine
关键词
非高密度脂蛋白胆固醇/低密度脂蛋白胆固醇比值
急性ST段抬高型心肌梗死
早发
男性
Ratio of non-high density lipoprotein cholesterol to high density lipoprotein cholesterol
Acute ST-segment elevation myocardial infarction
Early-onset
Men
