摘要
目的探讨色素框同源物7(CBX7)蛋白在宫颈癌(CC)组织中的表达及临床意义。方法回顾性收集2013至2020年在新疆医科大学第一附属医院初次诊断为CC并行宫颈切除术的71例CC组织标本。免疫组织化学法检测组织中CBX7的表达。同时收集患者的临床病理资料,跟踪随访后进行生存分析。结果CBX7在10例CC组织中高表达、19例组织中低表达、42例组织中阴性表达(P<0.05);CBX7的表达水平在不同临床分期、淋巴转移和脉管侵袭等临床病理特征上均有差异(P<0.05);与CBX7阴性表达和低表达组患者相比,CBX7高表达CC患者的生存率均明显提高(P<0.05),不同CBX7表达量的患者生存率间差异显著(P<0.05);结论CC组织中CBX7蛋白阴性表达可能与CC患者预后不佳有关。CC组织CBX7表达可能是一个影响CC患者生存的重要预后因素。
Objective To investigate the expression and clinical significance of chomobox homolog 7(CBX7)in cervical cancer(CC)tissues.Methods Tissue samples of 71 patients with CC who were first diagnosed with CC and underwent cervical resection in the First Affiliated Hospital of Xinjiang Medical University from 2013 to 2020 were retrospectively collected.The expression of CBX7 was detected by immunohistochemistry(IHC).At the same time,data of clinical pathology from the patients were collected and survival analysis was conducted after following-up.Results CBX7 was highly expressed in 10 CC tissues,moderately low in 19 CC tissues,and negative in 42 CC tissues(P<0.05).The expression of CBX7 was different and rlated to clinical stages,lymphatic metastasis and vascular invasion(P<0.05).Compared with the negative and low CBX7 expression groups,the survival rate of CC patients with high CBX7 expression was significantly enhanced(P<0.05)and the survival rate of patients with different CBX7 expression levels were significantly different(P<0.05).Conclusions The negative expression of CBX7 protein in CC tissues may be associated with poor prognosis of CC patients.CBX7 expression in CC tissues is a potential prognostic fact of CC patients.
作者
哈提米汗·买买提
姑丽克孜·买买提热夏提
李俞霆
周常慧
李榕
Hatimihan· MAIMAITI;Gulikezi·MAIMAITIREXIATI;LI Yu-ting;ZHOU Chang-hui;LI Rong(School of Public Health,Xinjiang Medical University,Urumqi 830000,China)
出处
《基础医学与临床》
2022年第5期721-725,共5页
Basic and Clinical Medicine
基金
国家自然科学基金(81760468)。
关键词
宫颈癌
CBX7的表达
预后
临床意义
cervical cancer
expression of CBX7
prognosis
clinical significance
