摘要
目的评价人乳头瘤病毒(HPV)基因分型与血清肿瘤标志物在宫颈癌诊断中的临床价值。方法选取166例宫颈疾病患者,其中宫颈癌39例,宫颈炎46例,宫颈上皮内瘤变(CIN)高度宫颈病变40例,CIN低度宫颈病变41例;另选取同期44例健康体检者作为对照组。所有受检者均进行HPV检测及血清肿瘤标志物检验,分析HPV分布情况和血清肿瘤标志物水平,主要包括糖类抗原125(CA125)、鳞状上皮细胞癌抗原(SCC-Ag)、癌胚抗原(CEA)、糖类抗原153(CA153)、糖类抗原199(CA199),并评价诊断效能。结果宫颈癌组、宫颈炎组、CIN高度宫颈病变组、CIN低度宫颈病变组、对照组HPV16、HPV52、HPV58、HPV39检出率比较差异具有统计学意义(P<0.05),HPV35检出率比较差异无统计学意义(P>0.05)。宫颈癌组CA125、SCC-Ag、CEA、CA153,CA199水平均显著高于宫颈炎组、CIN高度宫颈病变组、CIN低度宫颈病变组、对照组,差异具有统计学意义(P<0.05)。HPV与肿瘤标志物联合检测的准确性、敏感性分别为91.87%、94.36%,肿瘤标志物准确性、敏感性分别为76.25%、68.79%,HPV准确性、敏感性分别为80.06%、72.65%,联合检测的敏感性、准确性均显著高于单一检测方式,差异具有统计学意义(P<0.05)。结论在宫颈癌诊断中,HPV与血清肿瘤标志物均具有理想的诊断价值,联合检测后可进一步提升诊断准确性,且宫颈癌病变程度与HPV分型之间具有密切关联,值得临床借鉴。
Objective To evaluate the clinical value of human papillomavirus(HPV)genotyping and serum tumor markers in the diagnosis of cervical cancer.Methods 166 patients with cervical diseases were selected,including 39 cases of cervical cancer,46 cases of cervicitis,40 cases of high cervical lesions of cervical intraepithelial neoplasia(CIN)and 41 cases of low cervical lesions of CIN;Another 44 healthy persons in the same period were selected as the control group.All subjects were tested for HPV and serum tumor markers,analyzed the distribution of HPV and the level of serum tumor markers,mainly including carbohydrate antigen 125(CA125),squamous cell carcinoma antigen(SCC-Ag),carcinoembryonic antigen(CEA),carbohydrate antigen 153(CA153)and carbohydrate antigen 199(CA199),and evaluated the diagnostic efficacy.Results There were significant differences in the detection rates of HPV 16,HPV52,HPV58 and HPV39 among cervical cancer group,cervicitis group,CIN high cervical lesion group,CIN low cervical lesion group and control group(P<0.05),but there was no significant difference in the detection rate of HPV35(P>0.05).The levels of CA125,SCC-Ag,CEA,CA153 and CA199 in cervical cancer group were significantly higher than those in cervicitis group,CIN high cervical lesions group,CIN low cervical lesions group and control group(P<0.05).The accuracy and sensitivity of combined detection of HPV and tumor markers were 91.87%and 94.36%respectively,the accuracy and sensitivity of tumor markers were 76.25%and 68.79%respectively,and the accuracy and sensitivity of HPV were 80.06%and 72.65%respectively.The sensitivity and accuracy of combined detection were significantly higher than that of single detection(P<0.05).Conclusion HPV and serum tumor markers have ideal diagnostic value in the diagnosis of cervical cancer.Combined detection can further improve the diagnostic accuracy,and there is a close correlation between the degree of cervical cancer and HPV typing,which is worthy of clinical reference.
作者
杨萍灿
王伟
Yang Pingcan;Wang Wei(Department of Clinical Laboratory,Dongtai People's Hospital,Tancheng 224200,China)
出处
《实用妇科内分泌电子杂志》
2021年第10期66-69,共4页
Electronic Journal of Practical Gynecological Endocrinology
关键词
宫颈癌
人乳头瘤病毒
血清肿瘤标志物
检出率
诊断准确性
Cervical cancer
Human papillomavirus
Serum tumor markers
Detection rate
Diagnostic accuracy
