摘要
目的探究4种血清肿瘤标志物在宫颈癌诊断中的应用效果分析。方法方便选取宫颈癌患者120例为观察组,在该院于2016年1月—2018年12月进行诊断治疗,选择CA15-3、CA19-9、SCC、CA1254种血清肿瘤标志物,以及同时期的正常对照者(对照B组)、宫颈良性病变患者(对照A组),各36例。结果相较于对照A组、对照B组,观察组的CA125、CA15-3、SCC水平显著较高;相较于对照B组,对照A组的CA125、CA15-3、SCC水平明显较高,差异有统计学意义(P<0.05);3组间血清CA19-9水平对比,差异无统计学意义(P>0.05);单项使用检测患者CA15-3、CA19-9、SCC、CA1254种血清肿瘤标志物的灵敏度中最高的是SCC(41.80%),最低的是CA15-3(9.60%);在联合检测宫颈癌灵敏度中,选择血清SCC与CA125,发现SCC单项检测提升到58.1%,获得显著提升,但是特异性无明显变化。增加CA15-3、CA19-9联合检测,发现特异性有下降的趋势,并提高检测宫颈癌的灵敏度。选择血清CA19-9、CA15-3、SCC联合检测,或CA19-9、CA15-3、CA125检测,一些组合增加检测的特异性,但是相较于SCC与CA125,其灵敏度均明显较低。结论针对宫颈癌患者,采用CA15-3、CA19-9、SCC、CA1254种血清肿瘤标志物检测诊断,可显著改善患者的生活质量,有较高临床诊断价值,意义重大。
Objective To investigate the application effect of four serum tumor markers in the diagnosis of cervical cancer.Methods 120 patients with cervical cancer were convenienty selected as observation group.We were diagnosed and treated in the hospital from January 2016 to December 2018.Four serum tumor markers CA15-3,CA19-9,SCC and CA125 were selected.The normal controls(control group B)and the patients with benign cervical lesions(control group A)were 36 cases each.Results Compared with the control group A and the control group B,the levels of CA125,CA15-3 and SCC in the observation group were significantly higher.Compared with the control group B,the levels of CA125,CA15-3 and SCC in the control group A were significantly higher.The contrast difference was statistically significant(P<0.05);the difference of serum CA19-9 levels between the three groups was not statistically significant(P>0.05);the single test used patients CA15-3,CA19-9,SCC,CA125 four serum of the highest sensitivity of tumor markers was SCC(41.80%),and the lowest was CA15-3(9.60%).Among the sensitivity of combined detection of cervical cancer,serum SCC and CA125 were selected,and SCC single detection was found to increase to 58.1%,significantly improved,but the specificity did not change significantly.Increasing the combined detection of CA15-3 and CA19-9 revealed a trend of decreased specificity and improved sensitivity for detecting cervical cancer.Serum CA19-9,CA15-3,SCC combined detection,or CA19-9,CA15-3,CA125 detection,some combinations increased the specificity of detection,but the sensitivity was significantly lower than SCC and CA125.Conclusion For cervical cancer patients,the detection of CA15-3,CA19-9,SCC,CA125 four serum tumor markers can significantly improve the quality of life of patients,and has a high clinical diagnostic value.
作者
戴伟萍
林兰
DAI Wei-ping;LIN Lan(Nantong Cancer Hospital,Nantong,Jiangsu Province,226361 China)
出处
《中外医疗》
2019年第32期193-195,共3页
China & Foreign Medical Treatment
关键词
宫颈癌
临床应用
血清肿瘤标志物
Cervical cancer
Clinical application
Serum tumor markers
