摘要
目的探讨2型糖尿病(T2DM)患者的糖尿病视网膜病变(DR)患病率及危险因素。方法将行健康体检且既往确诊为T2DM的636例患者作为研究对象。收集患者的基本信息,测量患者的身高、体重、腰围和臀围,检测相关实验室指标,并拍摄患者免散瞳下、以眼底视乳头和黄斑为中心的眼底照片。计算T2DM患者的DR患病率。比较DR患者与非DR患者的一般资料和临床资料,并采用Logistic回归模型分析T2DM患者发生DR的危险因素。结果636例T2DM患者中发生DR 241例,DR患病率为37.89%。T2DM患者发生DR与尿蛋白、年龄、糖尿病病程、糖尿病发病年龄、空腹血糖、餐后2 h血糖、糖化血红蛋白、总胆固醇有一定关系(均P<0.05)。尿蛋白阳性、糖尿病病程长、空腹血糖升高、低龄及糖尿病发病年龄早是T2DM患者发生DR的独立危险因素(均P<0.05)。结论T2DM患者的DR患病率较高,尿蛋白阳性、糖尿病病程长、空腹血糖升高、低龄及糖尿病发病年龄早的患者发生DR的风险增加。
Objective To investigate the prevalence rate of and risk factors for diabetic retinopathy(DR)in patients with type 2 diabetes mellitus(T2DM).Methods A total of 636 patients who previously had been diagnosed with T2DM and had a physical examination were enrolled as research subjects.The general information of the patients was collected.A measurement was performed on the patients′body height,body weight,waist circumference and hip circumference,and the related laboratory indices were detected;in addition,the nonmydriatic fundus photography centered on fundus optic papilla and macula lutea were taken in the patients.The prevalence rate of DR was calculated in T2DM patients.The general data and clinical data were compared between DR patients and non-DR patients,and the Logistic regression model was used to analyze the risk factors for developing DR in T2DM patients.Results There were 241 cases of DR in the 636 patients with T2DM,and the prevalence rate of DR was 37.89%.Among patients with T2DM,the incidence of DR correlated with urinary protein,age,course of diabetes,diabetes onset age,fasting blood glucose,2-hour postprandial blood glucose,hemoglobin A1c,and total cholesterol(all P<0.05).Urinary protein-positive,a prolonged course of diabetes,elevated fasting blood glucose,younger age,and diabetes initiation at a younger age were independent risk factors for developing DR in T2DM patients(all P<0.05).Conclusion Patients with T2DM experience a higher prevalence rate of DR.Patients with urinary protein-positive,prolonged course of diabetes,elevated fasting blood glucose,younger age,or diabetes initiation at a younger age have an increased risk for developing DR.
作者
赖丽平
刘贺
黄锡岚
张伶
黄国秀
冯照发
李卫
LAI Li-ping;LIU He;HUANG Xi-lan;ZHANG Ling;HUANG Guo-xiu;FENG Zhao-fa;LI Wei(Health Management Center,Guangxi Academy of Medical Sciences&the People′s Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China)
出处
《广西医学》
CAS
2022年第4期370-375,共6页
Guangxi Medical Journal
基金
广西卫健委自筹经费科研课题(Z20190619)
广西人才小高地项目(桂组通字〔2019〕85-9)。
关键词
2型糖尿病
糖尿病视网膜病变
危险因素
患病率
Type 2 diabetes mellitus
Diabetic retinopathy
Risk Factor
Prevalence rate
