摘要
目的:观察桃红四物汤对胫腓骨骨折术后下肢深静脉血栓(DVT)的防治效果,以及对患者血清炎症因子、凝血功能的影响。方法:选取80例胫腓骨骨折患者,按随机数字表法分为观察组和对照组,每组40例。2组均采取内固定术治疗,对照组术后给予常规消肿药物及低分子肝素钙注射液治疗,观察组在对照组基础上加用桃红四物汤治疗。比较2组治疗前后血清白细胞介素-5 (IL-5)水平、白细胞介素-10 (IL-10)水平、凝血酶时间(TT)、凝血酶原时间(PT)、视觉模拟评分法(VAS)评分及患肢肿胀程度;比较2组下肢DVT、关节功能障碍、延迟愈合和感染发生率。结果:治疗后,2组血清IL-5、IL-10水平均较治疗前降低(P<0.05),观察组血清IL-5、IL-10水平均低于对照组(P<0.05)。治疗后,2组TT、PT均较治疗前延长(P<0.05),观察组TT、PT均长于对照组(P<0.05)。治疗后,2组VAS评分、患肢肿胀程度均较治疗前降低(P<0.05),观察组VAS评分、患肢肿胀程度均低于对照组(P<0.05)。观察组下肢DVT、延迟愈合、感染发生率均低于对照组(P<0.05)。2组关节功能障碍发生率比较,差异无统计学意义(P>0.05)。结论:桃红四物汤可减轻胫腓骨骨折术后患者机体的炎症反应,改善其凝血功能,缓解患肢疼痛、肿胀,减少下肢DVT等并发症发生。
Objective:To observe the prevention and treatment effect of Taohong Siwu tang on deep vein thrombosis(DVT) of lower extremities after operation for fracture of tibia and fibula,and the effect on serum inflammatory factors and coagulation function of patients. Methods:A total of 80 cases of patients with fracture of tibia and fibula were selected and divided into the observation group and the control group according to the random number table method,with 40 cases in each group. Both groups were treated with internal fixation. After operation, the control group was treated with routine medicines for detumescence and low molecular heparin calcium injection,and the observation group was additionally treated with Taohong Siwu tang based on the treatment of the control group. Before and after treatment,the levels of interleukin-5(IL-5) and interleukin-10(IL-10) in serum,thrombin time(TT),prothrombin time(PT),Visual Analogue Scale(VAS) scores and swelling degree of affected limbs in the two groups were compared. The incidences of DVT of lower extremities,joint dysfunction,delayed healing and infection in the two groups were compared. Results:After treatment,the levels of IL-5 and IL-10 in serum in the two groups were decreased when compared with those before treatment(P<0.05),and the above levels of inflammatory factors in the observation group were lower than those in the control group(P<0.05). After treatment,TT and PT in the two groups were prolonged when compared with those before treatment(P<0.05),and TT and PT in the observation group were longer than those in the control group(P<0.05). After treatment,VAS score and swelling degree of affected limbs in the two groups were decreased when compared with those before treatment(P<0.05),and VAS score and swelling degree of affected limbs in the observation group were lower than those in the control group(P<0.05). The incidences of DVT of lower extremities,delayed healing and infection in the observation group were lower than those in the control group(P<0.05). There was
出处
《新中医》
CAS
2022年第6期45-48,共4页
New Chinese Medicine
关键词
胫腓骨骨折术后
下肢深静脉血栓
桃红四物汤
炎症因子
凝血功能
疼痛
肿胀
并发症
After operation for fracture of tibia and fibula
Deep venous thrombosis of lower extremities
Taohong Siwu tang
Inflammatory factors
Coagulation function
Pain
Swelling
Complications
