摘要
目的:研究脑梗死患者血清超敏C反应蛋白(hs-CRP)、基质金属蛋白酶-9(MMP-9)、氧化修饰的低密度脂蛋白(ox-LDL)、白细胞介素-6(Interleukin-6,IL-6)水平与动脉粥样硬化程度的关系。方法:回顾性分析2019年1月-2020年9月淄博市第五人民医院诊断的96例脑梗死患者的临床资料为观察组,另选取同期健康体检的96例志愿者的临床资料为对照组。根据对患者的超声多普勒探查斑块情况,可将患者的粥样硬化情况分为:无斑块组35例,稳定斑块组27例,易损斑块组34例。比较观察组及对照组的血清hs-CRP、MMP-9、ox-LDL、IL-6水平;比较不同血管粥样硬化严重程度患者的血清hs-CRP、MMP-9、ox-LDL、IL-6水平;分析患者的血管粥样硬化严重程度与血清hs-CRP、MMP-9、ox-LDL、IL-6水平的相关性。结果:观察组血清hs-CRP、MMP-9、ox-LDL、IL-6水平均高于对照组,差异均有统计学意义(P<0.05)。无斑块组、稳定斑块组及易损斑块组的hs-CRP、MMP-9、ox-LDL、IL-6水平比较,差异均有统计学意义(P<0.05)。易损斑块组的血清hs-CRP、MMP-9、ox-LDL、IL-6水平均高于稳定斑块组及无斑块组,且稳定斑块组均高于无斑块组,差异均有统计学意义(P<0.05)。通过相关性分析,患者的粥样硬化程度与血清hs-CRP、MMP-9、ox-LDL、IL-6水平均呈正相关(P<0.05)。结论:脑梗死患者血清hs-CRP、MMP-9、ox-LDL、IL-6水平与动脉粥样硬化程度显著相关,可作为日后疾病病情分析的重要依据之一。
Objective:To study the relationship between serum hypersensitive-CRP (hs-CRP),matrix metalloproteinase-9 (MMP-9),ox-LDL,interleukin-6 (IL-6) levels and the degree of atherosclerosis in cerebral infarction patients.Method:The clinical data of 96 patients with cerebral infarction diagnosed in the Zibo Fifth People’s Hospital from January 2019 to September 2020 were retrospectively analyzed as the observation group,and the clinical data of 96 healthy volunteers during the same period were selected as the control group.According to the status of the plaques detected by ultrasound doppler,the atherosclerosis of the patients could be divided into 35 patients no plaque group,27 patients with stable plaque group,and 34 patients with vulnerable plaque group.The serum levels of hs-CRP,MMP-9,ox-LDL and IL-6 in the observation group and the control group were compared;the serum levels of hs-CRP,MMP-9,ox-LDL and IL-6 in patients with different severity of atherosclerosis were compared;the correlation between the severity of atherosclerosis and serum levels of hs-CRP,MMP-9,ox-LDL and IL-6 was analyzed.Result:The serum levels of hs-CRP,MMP-9,ox-LDL and IL-6 in the observation group were higher than those in the control group,the differences were statistically significant (P<0.05).There were statistically significant differences in hs-CRP,MMP-9,ox-LDL and IL-6 levels among no plaque group,stable plaque group and vulnerable plaque group (P<0.05).Serum hs-CRP,MMP-9,ox-LDL and IL-6 levels in the vulnerable plaque group were higher than those in stable plaque group and no plaque group,and those in the stable plaque group were higher than those in the in no plaque group,the differences were statistically significant (P<0.05).Correlation analysis showed that the degree of atherosclerosis were positively correlated with the serum levels of hs-CRP,MMP-9,ox-LDL and IL-6 (P<0.05).Conclusion:The serum levels of hs CRP,MMP-9,ox-LDL and IL-6 in patients with cerebral infarction are significantly correlated with the degree of atherosclerosi
作者
司衍刚
房辉
SI Yan’gang;FANG Hui(Zibo Fifth People’s Hospital,Shandong Province,Zibo 255120,China;不详)
出处
《中国医学创新》
CAS
2022年第9期66-70,共5页
Medical Innovation of China
