摘要
目的探讨抗载脂蛋白A1抗体(Anti-apolipoprotein A-1 Ig G,抗apo A-1 Ig G)、基质金属蛋白酶9(metalloproteinase-9,MMP-9)与急性脑梗死患者颈动脉粥样硬化的相关性。方法选择急性脑梗死患者120例,采用彩色多普勒超声检测患者颈部血管,观察颈动脉内-中膜厚度(Intima-median thickness,IMT)及斑块性质,并分为4组:IMT正常组(颈动脉正常组)、IMT增厚组、稳定斑块组、不稳定斑块组,其中后3组为颈动脉粥样硬化组。用ELISA方法检测抗apo A-1 Ig G、MMP-9的表达水平。结果颈动脉粥样硬化组的抗apo A-1 Ig G、MMP-9的表达水平明显高于颈动脉正常组(P<0.05);4组中由1组到4组的抗apo A-1 Ig G、MMP-9的表达水平依次升高(P<0.01);分别以IMT、斑块稳定性为因变量,以动脉粥样硬化相关的危险因素作为自变量做Logistic回归分析,结果示抗apo A-1 Ig G、MMP-9是颈动脉粥样硬化、斑块不稳定的独立危险因素[抗apo A-1 Ig G(μg/ml)OR=23.226,95%CI 4.204~128.305,P<0.01,MMP-9(ng/ml)OR=2.287,95%CI 0.890~5.872,P<0.05;抗apo A-1 Ig G(μg/ml)OR=3.301,95%CI 1.212~8.991,P<0.01,MMP-9(ng/ml)OR=2.345,95%CI 1.129-4.871,P<0.05]。抗apo A-1 Ig G、MMP-9血清水平与颈动脉粥样硬化程度呈正相关(抗apo A-1 Ig G:r=0.407,P<0.01;MMP-9:r=0.316,P<0.01)。结论抗apo A-1 Ig G、MMP-9是脑梗死患者颈动脉粥样硬化的独立危险因素,与脑梗死患者颈动脉粥样硬化程度呈正相关。检测二者的浓度可能成为发现早期动脉粥样硬化的方法。
Objective To explore the relationship between anti-apolipoprotein A1 antibody（ Anti-apolipoprotein A-1 Ig G,anti-apo A-1 Ig G）,metalloproteinase9（ metalloproteinase-9,MMP-9） and carotid atherosclerosis in patients with acute cerebral infarction. Methods Select 120 cases of acute cerebral infarction in my department,and use color doppler ultrasound to check the patients＇ cervical blood vessels. The patients with acute cerebral infarction were divided into four groups by observing the intimal thickness and the nature of the plaques： normal endometrium（ normal carotid artery group）,endometrial thickening group,stable plaque group,unstable plaque group. The last three groups were carotid atherosclerosis. Use ELISA to detect the expression level of anti-apo A-1 Ig G and MMP-9. Results The expression levels of anti-apo A-1 Ig G and MMP-9 in the carotid atherosclerosis group were significantly higher than that in the normal carotid artery group（ P〈0. 01）. The expression levels of anti apo A-1 Ig G and MMP-9 in the 4 groups from 1 groups to 4 groups increased in turn（ P〈0. 01）. Taking IMT and plaque stability as dependent variable and atherosclerosis related risk factors as independent variables,logistic regression analysis. The results showed that apo A-1 Ig G and MMP-9 were independent risk factors for carotid atherosclerosis and plaque instability[anti-apo A-1 Ig G（ μg/ml） OR = 23. 226,95% CI 4. 204 ~ 128. 305,P〈0. 01,MMP-9（ ng/ml） OR = 2. 287,95% CI 0. 890 ~ 5. 872,P〈0. 05; anti-apo A1 Ig G（ μg/ml） OR = 3. 301,95% CI 1. 212 ~ 8. 991,P〈0. 01; MMP-9（ ng/ml） OR = 2. 345,95% CI 1. 129 ~ 4. 871,P〈0. 05]. There was a positive correlation between the serum level of anti apo A-1 Ig G and MMP-9 and the degree of carotid atherosclerosis（ anti-apo A1 Ig G： r = 0. 407,P〈0. 01;MMP-9： r = 0. 316,P〈0. 01）. Conclusion Anti apo A-1 Ig G and MMP-9 are independent risk factors for carotid atherosclerosis in patients with cerebral infarction,and are positively correlated
出处
《中风与神经疾病杂志》
CAS
2018年第2期141-144,共4页
Journal of Apoplexy and Nervous Diseases
基金
内蒙古自治区自然科学基金项目(2017MS0858)
