摘要
目的:探讨重复经颅磁刺激(rTMS)联合度洛西汀治疗躯体形式障碍(SD)患者的效果。方法:选取80例SD患者为研究对象,按随机数字表法分为对照组、观察组各40例。对照组口服盐酸度洛西汀肠溶胶囊治疗,观察组在其基础上联合rTMS治疗,两组均连续治疗4周。比较两组临床疗效、汉密尔顿焦虑量表(HAMA)评分、汉密尔顿抑郁量表(HAMD)评分、生活质量综合评定问卷(GQOLI-74)评分及不良反应发生率。结果:观察组治疗总有效率为95.00%(38/40),高于对照组的77.50%(31/40),差异有统计学意义(P<0.05);治疗后,观察组HAMA、HAMD评分低于对照组,GQOLI-74各维度评分高于对照组,差异均有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:rTMS联合度洛西汀治疗SD患者效果显著,可减轻其焦虑、抑郁症状,促进其躯体症状缓解,有效改善其生命质量,安全可行,效果优于单用度洛西汀治疗。
Objective:To explore efficacy of repetitive transcranial magnetic stimulation(rTMS)combined with Duloxetine in treatment of somatoform disorders(SD).Methods:80 SD patients were selected as the research objects and were divided into control group and observation group according to the random number table method,40 cases in each group.The control group was treated with Duloxetine hydrochloride entericcoated capsules orally,while the observation group was treated with rTMS on this basis.Both groups were treated continuously for 4 weeks.The clinical efficacy,the Hamilton anxiety scale(HAMA)score,the Hamilton depression scale(HAMD)score,the general quality of life inventory-74(GQOLI-74)score and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 95.00%(38/40),which was higher than the control group of 77.50%(31/40),and the difference was statistically significant(P<0.05).After the treatment,the HAMA and the HAMD scores of the observation group were lower than those of the control group;the scores of GQOLI-74 each dimension were higher than those of the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in adverse reactions between the two groups(P>0.05).Conclusions:rTMS combined with Duloxetine in the treatment of the SD patients has a significant effect,which can reduce their anxiety and depression symptoms,promote the relief of their somatic symptoms,and effectively improve their quality of life.Moreover,it is safe and feasible.Further,Moreover,it is superior to single Duloxetine.
作者
姜卓然
JIANG Zhuoran(Department of Psychiatry of Anshan Mental Health Center,Anshan 114000 Liaoning,China)
出处
《中国民康医学》
2022年第6期67-69,共3页
Medical Journal of Chinese People’s Health
关键词
躯体形式障碍
重复经颅磁刺激
度洛西汀
焦虑
抑郁
Somatoform disorder
Repetitive transcranial magnetic stimulation
Duloxetine
Anxiety
Depression
