摘要
目的观察针刺温通法联合米氮平治疗难治性抑郁症的临床疗效。方法将80例难治性抑郁症患者随机分为两组(治疗组和对照组),每组40例。对照组采用口服米氮平片治疗;治疗组在对照组治疗基础上联合针刺温通法。比较两组治疗前后汉密尔顿抑郁量表(HAMD)评分、生活质量综合评定问卷评分(GQOLI-74)及血清5-羟色胺(5-HT)、脑源性神经营养因子(BDNF)、白介素6(IL-6)水平的变化。比较两组临床疗效。结果两组治疗后HAMD评分和血清IL-6水平较同组治疗前显著降低(P<0.05),生活质量评分(躯体、心理、社会和物质生活)以及血清5-HT、BDNF水平均较同组治疗前显著升高(P<0.05)。治疗后,治疗组HAMD评分和血清IL-6水平明显低于对照组(P<0.05),而生活质量评分(躯体、心理、社会和物质生活)以及血清5-HT、BDNF水平均明显高于对照组(P<0.05)。治疗组总有效率(70.0%)高于对照组(47.5%),差异有统计学意义(P<0.05)。结论针刺温通法联合米氮平治疗难治性抑郁症的疗效优于单纯米氮平治疗,可改善抑郁症状,提高生活质量,可能与调节血清5-HT、BDNF和IL-6水平相关。
Objective To observe the clinical efficacy of acupuncture with warm unblocking method plus Mirtazapine in treating treatment-resistant depression.Method Eighty patients with treatment-resistant depression were randomized into two groups(treatment and control groups),with 40 cases in each group.The control group was treated with oral administration of Mirtazapine,and the treatment group was given additional acupuncture with warm unblocking method based on the control group.Before and after the treatment,the Hamilton depression scale(HAMD)score,generic quality of life inventory 74(GQOLI-74)score,and the levels of serum 5-hydroxytryptamine(5-HT),brain-derived neurotrophic factor(BDNF),and interleukin(IL)-6 were compared.The clinical efficacy was also compared between the two groups.Result The HAMD score and serum IL-6 level dropped significantly after the treatment in both groups(P<0.05),and the quality of life scores(physical body,mental,social,and material life)and serum levels of 5-HT and BDNF increased significantly(P<0.05).After the treatment,the HAMD score and serum IL-6 level were markedly lower in the treatment group than in the control group(P<0.05),and the quality of life scores(physical body,mental,social,and material life)and serum levels of 5-HT and BDNF were markedly higher in the treatment group(P<0.05).The total effective rate in the treatment group(70.0%)was higher than that in the control group(47.5%),and the difference was statistically significant(P<0.05).Conclusion Acupuncture with warm unblocking method plus Mirtazapine can produce more significant efficacy than Mirtazapine alone in treating treatment-resistant depression.It can improve depressive symptoms and enhance the quality of life,which may be associated with the regulation of serum 5-HT,BDNF,and IL-6 levels.
作者
朱凤英
牛梦娣
马燕
杜欣茹
孙凌志
张叶
ZHU Fengying;NIU Mengdi;MA Yan;DU Xinru;SUN Lingzhi;ZHANG Ye(Hebei Hengshui Mental Hospital,Hengshui 053000,China)
出处
《上海针灸杂志》
2022年第4期348-352,共5页
Shanghai Journal of Acupuncture and Moxibustion
基金
河北省中医药管理局课题(2020543)。
关键词
针刺疗法
提插捻转法
针药并用
抑郁症
5-羟色胺
白介素6
脑源性神经营养因子
Acupuncture therapy
Lifting-thrusting and twisting manipulations
Acupuncture medication combined
Depression
5-hydroxytryptamine
Interleukin-6
Brain-derived neurotrophic factor