摘要
目的探讨老年冠心病(CHD)合并2型糖尿病(T2DM)患者英国前瞻性糖尿病研究(UKPDS)评分和平均血小板体积(MPV)变化与冠状动脉狭窄程度的相关性,为临床诊疗提供指导。方法选择2017年4月至2020年5月在浙江绿城心血管病医院行冠状动脉造影术的136例CHD合并T2DM患者(年龄>60岁)为研究对象。根据Gensini评分结果将患者分为高分组(Gensini评分≥40分)54例和低分组(Gensini评分<40分)82例。采用UKPDS评分系统评估患者10年冠心病风险(CHDRISK),分析比较两组患者CHDRISK值和MPV情况及其与冠状动脉狭窄程度的相关性。结果两组患者的年龄、收缩压、舒张压、低密度脂蛋白胆固醇(LDL-C)、血清总胆固醇(TC)比较,差异无统计学意义(P>0.05);两组患者的吸烟史、糖尿病病程、空腹血糖(FPG)、高密度脂蛋白固醇(HDL-C)、三酰甘油(TG)、糖化血红蛋白(HbA1c)比较,差异有统计学意义(P<0.05)。高分组患者CHDRISK值和MPV水平均明显高于低分组,差异有统计学意义(P<0.05,P<0.001)。Pearson相关分析显示,患者Gensini评分与CHDRISK值(r=0.217,P<0.001)和MPV水平(r=0.336,P<0.001)均呈正相关。结论老年CHD合并T2DM患者UKPDS评分和MPV变化与冠状动脉狭窄程度密切相关,两项指标的分析检测对CHD合并T2DM患者病情评估具有一定价值。
Objective To investigate the correlation between the changes of the UK prospective diabetes study(UKPDS)score and mean platelet volume(MPV)with the degree of coronary artery stenosis in elderly patients with coronary heart disease(CHD)complicated with type 2 diabetes mellitus(T2DM),so as to provide guidance for clinical diagnosis and treatment.Methods A total of 136 patients(>60 years old)with CHD complicated with T2DM who underwent coronary angiography in Zhejiang Greentown Cardiovascular Hospital from April 2017 to May 2020 were selected as research objects.According to the results of Gensini score,the patients were divided into the high score group(Gensini score≥40,n=54)and the low score group(Gensini score<40,n=82).The 10-year coronary heart disease risk(CHDRISK)was evaluated by the UKPDS scoring system.CHDRISK and MPV were analyzed and compared between the two groups,and their correlation with the degree of coronary artery stenosis was analyzed.Results There were no statistically significant differences in age,systolic blood pressure,diastolic blood pressure,low density lipoprotein cholesterol(LDL-C)and serum total cholesterol(TC)between the two groups(P>0.05),but there were statistically significant differences in smoking history,course of diabetes,fasting blood glucose(FPG),high density lipoprotein sterol(HDL-C),triglyceride(TG)and glycosylated hemoglobin(HbA1c)between the two groups(P<0.05).The CHDRISK value and MPV level of the patients in the high score group were significantly higher than those in the low score group,with statistically significant differences(P<0.05).Pearson correlation analysis showed that the Gensini score was positively correlated with CHDRISK value(r=0.217,P<0.05)and MPV level(r=0.336,P<0.05).Conclusion The changes of UKPDS score and MPV in elderly patients with CHD complicated with T2DM are closely related to the degree of coronary artery stenosis.The analysis and detection of the two indexes has a certain value in evaluating the condition of patients with CHD complicated with T
作者
刘小慧
何浪
吴研
LIU Xiaohui;HE Lang;WU Yan(Department of Cardiovascular Medicine,Zhejiang Greentown Cardiovascular Hospital,Hangzhou310000,China;Department of Endocrinology,Zhejiang Greentown Cardiovascular Hospital,Hangzhou310000,China)
出处
《中国现代医生》
2022年第8期20-23,共4页
China Modern Doctor
基金
浙江省医药卫生科技计划项目(2017KY561)。
关键词
CHD
T2DM
UKPDS
MPV
冠状动脉狭窄
Coronary heart disease
Type 2 diabetes mellitus
UK prospective diabetes study
Mean platelet volume
Coronary artery stenosis
