摘要
探讨了急性缺血性脑卒中(AIS)后抑郁(PSD)的相关危险因素及其预测指标。选取保定市第四中心医院神经内科2019年1月—2020年6月收治的急性缺血性脑卒中患者116例,于发病后6个月按是否发生PSD分为PSD组(42例)和NPSD组(74例),比较两组一般资料、入院24 h内实验室指标检验结果和神经功能指标,对PSD相关因素进行单因素分析及Logistic回归分析,采用Pearson相关性分析与受试者工作(ROC)曲线对相关数据进行了统计分析。结果显示:两组性别、年龄、合并高脂血症、合并冠心病、卒中首次发病占比、既往精神疾病家族史占比、纤维蛋白原(FIB)、总胆固醇(TC)水平、低密度脂蛋白胆固醇(LDL-C)水平、超敏C反应蛋白(Hs-CRP)水平、同型半胱氨酸(Hcy)水平、美国国立卫生研究院卒中量表(NIHSS)评分差异均有统计学意义(P<0.05),Logistic回归分析结果显示合并冠心病、卒中发生次数、NIHSS评分、Hs-CRP、Hcy为PSD发生的独立危险因素(P<0.05)。相关性分析显示汉密顿抑郁量表(HAMD)评分与Hcy、Hs-CRP均呈正相关(r取0.541和0.489,P<0.05)。由ROC曲线分析得知Hcy联合Hs-CRP预测PSD的效能均优于单一指标。研究表明:PSD发生与合并冠心病、卒中发生次数、神经功能缺损程度、Hcy、Hs-CRP水平密切相关,检测Hcy、Hs-CRP水平在预测PSD发生风险中具有重要价值。
The purpose of this paper is to explore the related risk factors and predictive factors of acute ischemic stroke(AIS)post-stroke depression(PSD).116 patients with acute ischemic stroke admitted to the Department of Neurology in Baoding Fourth Central Hospital from January 2019 to June 2020 were selected as research targets,and they were divided into PSD group(42 cases)and NPSD group(74 cases)according to whether PSD occurred 6 months after the onset.Compared two groups of general information,laboratory index test results within 24 hours of admission,and neurological function indexes,single factor analysis and logistic regression analysis on PSD related factors were conducted,and Spearman correlation analysis and receiver operating curve(ROC curve)analysis perform statistical analysis on relevant data were used.Two groups of sex,age,combined with hyperlipidemia,combined with coronary heart disease,the proportion of first stroke,the proportion of family history of previous mental illness,fibrinogen(FIB),total cholesterol(TC)level,low-density lipoprotein cholesterol(LDL-C)levels,high-sensitivity C-reactive protein(Hs-CRP)levels,homocysteine(Hcy)levels,and National Institutes of Health Stroke Scale(NIHSS)scores were all significantly different(P<0.05).Logistic regression analysis showed that combined coronary heart disease,number of strokes,NIHSS score,Hs-CRP,and Hcy were independent risk factors for PSD(P<0.05).Correlation analysis showed that Hamilton Depression Rating Scale(HAMD)scores were positively correlated with Hcy and Hs-CRP(r=0.541,0.489,P<0.05).According to the ROC curve analysis,the efficacy of Hcy combined with Hs-CRP in predicting PSD is better than a single index.The occurrence of PSD is closely related to coronary heart disease,the number of strokes,the degree of neurological impairment,Hcy and Hs-CRP levels.The detection of Hcy and Hs-CRP levels has important value in predicting the risk of PSD.
作者
王宁
和杰
郭娜
WANG Ning;HE Jie;GUO Na(Baoding Fourth Central Hospital,Baoding 072350,China)
出处
《甘肃科学学报》
2022年第2期61-65,共5页
Journal of Gansu Sciences
