摘要
Magnesium alloys with integration of degradability and good mechanical performance are desired for vascular stent application.Drug-eluting coatings may optimize the corrosion profiles of magnesium substrate and reduce the incidence of restenosis simultaneously.In this paper,poly(trimethylene carbonate)(PTMC)with different molecular weight(50,000 g/mol named as PTMC5 and 350,000 g/mol named as PTMC35)was applied as drug-eluting coatings on magnesium alloys.A conventional antiproliferative drug,paclitaxel(PTX),was incorporated in the PTMC coating.The adhesive strength,corrosion behavior,drug release and biocompatibility were investigated.Compared with the PLGA control group,PTMC coating was uniform and gradually degraded from surface to inside,which could provide long-term protection for the magnesium substrate.PTMC35 coated samples exhibited much slower corrosion rate 0.05μA/cm^(2)in comparison with 0.11μA/cm^(2)and 0.13μA/cm^(2)for PLGA and PTMC5 coated counterparts.In addition,PTMC35 coating showed more stable and sustained drug release ability and effectively inhibited the proliferation of human umbilical vein vascular smooth muscle cells.Hemocompatibility test indicated that few platelets were adhered on PTMC5 and PTMC35 coatings.PTMC35 coating,exhibiting surface erosion behavior,stable drug release and good biocompatibility,could be a good candidate as a drug-eluting coating for magnesium-based stent.
基金
This work was supported by the National Key R&D Program of China(2018YFC1106600)
the National Natural Science Foundation of China(52071008,11827803)
Beijing Natural Science Foundation(2192027)
Young Elite Scientists Sponsorship Program By CAST(2017QNRC001).
