摘要
目的:探讨七氟醚联合右美托咪定对全身麻醉乳腺癌根治术患者免疫功能、血流动力学的影响。方法:选取南阳医学高等专科学校第一附属医院2019年10月至2021年3月期间收治的100例女性乳腺癌手术患者,根据用药方案不同将患者分为观察组与对照组,各50例。对照组给予右美托咪定全身麻醉维持;观察组给予七氟醚联合右美托咪定全身麻醉维持,比较两组患者手术不同时间的免疫球蛋白G(IgG)、分化簇3^(+)(CD3^(+))、CD4^(+)、CD8^(+)水平、CD4^(+)/CD8^(+)比值、一氧化碳(NO)、收缩压(SBP)、肾上腺皮质激素(ACTH)、平均动脉压(MAP)、心率(HR)、血氧饱和度(SaO_(2))。结果:术前两组患者的IgG、ACTH、CD8^(+)、NO、CD3^(+)水平和CD4^(+)/CD8^(+)比值比较,差异无统计学意义(P>0.05);术后3 d观察组患者的IgG、CD8^(+)、CD3^(+)水平和CD4^(+)/CD8^(+)比值高于对照组,差异具有统计学意义(P<0.05);ACTH、NO水平低于对照组,差异具有统计学意义(P<0.05)。麻醉诱导前(T0)两组患者的SBP、HR、MAP、SaO_(2)比较,差异无统计学意义(P>0.05)。麻醉维持后(T1)1 min观察组患者的SaO_(2)、MAP高于对照组,差异具有统计学意义(P<0.05)。麻醉维持后(T2)30 min观察组患者的SBP、HR、SaO_(2)、MAP高于对照组,差异具有统计学意义(P<0.05)。结论:全身麻醉乳腺癌根治术中采用七氟醚联合右美托咪定进行麻醉维持的效果良好确切,可有效维持患者术中循环稳定性,减轻手术应激及手术对患者免疫功能的影响。
Objective To investigate the effects of sevoflurane combined with dexmedetomidine on immune function and hemodynamics of patients undergoing radical mastectomy under general anesthesia for breast cancer.Methods A total of 100 female breast cancer patients admitted to the First Affiliated Hospital of Nanyang Medical College from October 2019 to March 2021 were selected,and they were divided into observation group and control group according to different medication regimens,with 50 patients in each group.The control group received dexmedetomidine general anesthesia maintenance and the observation group received sevoflurane combined with dexmedetomidine general anesthesia maintenance.Immunoglobulin G(IgG),differentiation cluster 3^(+)(CD3^(+)),CD4^(+),CD8^(+),CD4^(+)/CD8^(+),nitric oxide(NO),systolic blood pressure(SBP),adrenocorticotropic hormone(ACTH),mean arterial pressure(MAP),heart rate(HR)and blood oxygen saturation(SaO_(2))were compared between the two groups.Results There were no significant differences in the levels of IgG、ACTH、CD8^(+)、NO、CD3^(+)、and the ratio of CD4^(+)/CD8^(+)between the two groups before surgery,and the differences were statistically significant(P>0.05).Three days after operation,the levels of IgG,CD8^(+),CD3^(+),and the ratio of CD4^(+)/CD8^(+)in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).The levels of ACTH and NO were lower than those in the control group,and the differences were statistically significant(P<0.05).There were no significant differences in SBP,HR,MAP and SaO_(2) between the two groups before anesthesia induction(P>0.05).SaO_(2) and MAP in the observation group were higher than those in the control group 1 min after anesthesia maintenance,and the differences were statistically significant(P<0.05).SBP,HR,SaO_(2) and MAP of the observation group were higher than those of the control group 30 min after anesthesia maintenance,and the differences were statistically significant(P<0.05).Conclu
作者
陈晓林
张沛重
CHEN Xiao-lin;ZHANG Pei-zhong(The First Affiliated Hospital of Nanyang Medical College,Henan Nanyang 473000)
出处
《深圳中西医结合杂志》
2022年第3期34-37,共4页
Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
关键词
乳腺癌根治术
七氟醚
右美托咪
Radical mastectomy
Sevoflurane
Dexmedetomidine
