摘要
目的探索河北省HIV感染者和艾滋病(acquired immunodeficiency syndrome,AIDS)病例中未接受和已接受艾滋病抗病毒治疗人群的群体特征和生存时间。方法采用回顾性队列研究,比较未接受和已接受抗病毒治疗人群人口社会学特征、生存及死亡情况。通过单因素和多因素分析研究未接受抗病毒治疗的影响因素。通过生存曲线和log-rank检验描述人群生存情况。结果1989—2018年河北省累计报告病例中未接受抗病毒治疗病例2814例,接受抗病毒治疗病例10556例。性别、传播途径、文化程度、婚姻状况、样本来源、报告年份是影响抗病毒治疗的因素;不同发现年份病例接受抗病毒治疗比例逐年递增;未接受治疗病例的病死率为9.15/(100人·年),中位生存时间为(174.96±8.24)月。接受抗病毒治疗病例的病死率为0.99/(100人·年),中位生存时间为(295.17±3.81)月。发现时年龄在51岁以上生存时间(83.79±4.72)月,明显少于其他组。初始CD4细胞计数≥500个/μl的平均生存时间最长,为(257.76±3.06)月,<200个/μl的平均生存时间最短,仅(25.56±2.46)月。结论HIV/AIDS病例未接受抗病毒治疗受多种因素影响,降低了生存率;未治疗人群中,不同发现时年龄、不同初始CD4细胞计数的病例生存时间不同。应进一步加大宣传力度,做好治疗宣教,扩大检测,做到早发现、早治疗。
Objective To explore the population characteristics and survival time of HIV-infected people and AIDS patients in Hebei Province who have not received and have received anti-virus treatment.Methods A retrospective cohort study was conducted to compare the demographic sociological characteristics,survival and mortality of people receiving and not receiving antiviral treatment.Univariate and multivariate analyses were used to study the factors that influence the absence of antiviral therapy.The survival curve and log-rank test were used to describe the population survival.Results From 1989 to 2018,a total of 2814 reported cases without antiviral treatment and 10556 cases with antiviral treatment were reported in Hebei Province.Gender,transmission route,education level,marital status,sample source and reporting year were the factors that affected the antiviral therapy.The proportion of cases receiving antiviral treatment increased year by year in different years.The case fatality rate of untreated cases was 9.15/(100 person·year),and the median survival time was(174.96±8.24)months.The case fatality rate of patients receiving antiviral therapy was 0.99/(100 person·year)and the median survival time was(295.17±3.81)months.The survival time was(83.79±4.72)months in the group with age above 51 at the time of discovery,which was significantly less than the other groups.The longest mean survival time was(257.76±3.06)months with an initial CD4 cell count≥500/μl,and the shortest mean survival time was(25.56±2.46)months<200/μl.Conclusion The non-antiviral treatment of HIV/AIDS cases is affected by many factors that reduce survival rates.The survival time of cases in the untreated population varied with age at different discoveries and with different initial CD4 cell counts.We should further strengthen the publicity,do a good job in treatment publicity and education,expand detection,and achieve early detection and treatment.
作者
马琳
张亚丽
王伟
王校丰
吴小雪
MA Lin;ZHANG Ya-li;WANG Wei;WANG Xiao-feng;WU Xiao-xue(Department of STD/AIDS Control and Prevention,Hebei Center for Disease Control and Prevention,Shijiazhuang 050021,China)
出处
《医学动物防制》
2022年第1期9-13,共5页
Journal of Medical Pest Control
基金
河北省卫计委医学科研项目(20170451)。
关键词
HIV感染者
AIDS病例
抗病毒治疗
流行特征
生存时间
分析
HIV-infected people
AIDS cases
Highly active antiretroviral treatment
Epidemic characteristics
Survival time
Analysis
