摘要
目的探讨糖皮质激素辅助阿奇霉素在儿童肺炎支原体感染性大叶性肺炎中的应用效果。方法选取2019年6月至2021年6月南通市通州区人民医院儿科收治的80例支原体感染性大叶性肺炎患儿为研究对象。采取随机数字表法将患儿分为试验组与对照组,各40例。两组患儿都采取物理降温或者镇痛解热、平喘化痰等基础治疗。对照组给予阿奇霉素治疗;试验组在对照组的基础上给予糖皮质激素治疗。比较两组患儿治疗后的临床疗效、退热时间、咳嗽缓解时间、肺部啰音消失时间、住院时间以及不良反应发生情况;比较两组患儿治疗前后的C反应蛋白(CRP)、红细胞沉降率(ESR)、降钙素原(PCT)水平。结果试验组的治疗总有效率高于对照组,差异有统计学意义(P<0.05)。试验组的咳嗽缓解时间、住院时间、退热时间及肺部啰音消失时间均短于对照组,差异有统计学意义(P<0.05)。治疗前两组患儿的CRP、ESR及PCT水平比较,差异无统计学意义(P>0.05)。治疗后,两组患儿的CRP、ESR及PCT水平均低于本组治疗前,差异有统计学意义(P<0.05);且试验组的CRP、ESR及PCT水平均低于对照组,差异有统计学意义(P<0.05)。试验组的不良反应总发生率低于对照组,差异有统计学意义(P>0.05)。结论糖皮质激素辅助阿奇霉素治疗儿童肺炎支原体感染性大叶性肺炎,不但可以有效调节患儿的免疫功能,减少炎症因子释放,缩短治疗时间,提升疗效,而且不会增加治疗过程中的不良反应,值得临床应用。
Objective To explore the application effect of glucocorticoid assisted Azithromycin in children with Mycoplasma pneumoniae infected lobar pneumonia.Methods A total of 80 children with mycoplasma-infected lobar pneumonia admitted to the Department of Pediatrics of Tongzhou District People′s Hospital of Nantong City from June 2019 to June 2021 were selected as the research objects.A random number table method was used to divide children into the experimental group and the control group,40 cases in each group.Both groups were given basic treatment such as physical cooling or analgesia and fever,relieving asthma and resolving phlegm.The control group was given Azithromycin treatment,the experimental group was given glucocorticoid treatment on the basis of the control group.The clinical efficacy,antipyretic time,cough relief time,pulmonary rales disappearance time,hospitalization time,occurrence of adverse reactions after treatment were compared between the two group.The C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),procalcitonin(PCT)levels were compared between the two groups before and after treatment.Results The total effective rate of the experimental group was higher than that of the control group,and the difference was statistically significant(P<0.05).The cough relief time,hospitalization time,fever reduction time and lung rales disappearance time in the experimental group were all shorter than those in the control group,and the differences were statistically significant(P<0.05).There were no significant differences in the levels of CRP,ESR and PCT between the two groups before treatment(P>0.05).After treatment,the levels of CRP,ESR and PCT in the two groups were lower than those before treatment and the differences were statistically significant(P<0.05).And the CRP,ESR and PCT levels of the experimental group were lower than those of the control group,and the differences were statistically significant(P<0.05).The total incidence of adverse reactions in the experimental group was lower than that
作者
李雪娟
LI Xuejuan(Department of Pediatrics,Tongzhou District People′s Hospital,Jiangsu Province,Nantong226300,China)
出处
《中国当代医药》
CAS
2022年第9期23-26,共4页
China Modern Medicine
关键词
阿奇霉素
甲泼尼龙琥珀酸钠
肺炎支原体
大叶性肺炎
Azithromycin
Methylprednisolone Sodium Succinate
Mycoplasma pneumoniae
Lobar pneumonia
